eF-site ID 4hcb-ABCD PDB Code 4hcb Chain A, B, C, D click to enlarge Title The metal-free form of crystal structure of E.coli ExoI-ssDNA complex Classification HYDROLASE/DNA Compound Exodeoxyribonuclease I Source Escherichia coli (strain K12) (4HCB) Sequence A:  QQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEP EVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAA RIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAW SWQHDNSRWDLLDVMRACYALRPEGINWPENLPSFRLEHL TKANGIEDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNK HKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPE NRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNA AVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNL KILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSD ADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARN FPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQY ADDKEKVALLKALWQYADEIVH B:  QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPE VFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAAR IHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWS WQHDNSRWDLLDVMRACYALRPEGINWPENLPSFRLEHLT KANGIEDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKH KLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPEN RNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAA VPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLK ILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDA DRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNF PGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYA DDKEKVALLKALWQYADEIVH C:  AAAAAAAAAAAA D:  AAAAAAAAAAAA Description Functional site 1) chain A residue 430 type sequence H description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 2) chain A residue 433 type sequence Q description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 3) chain B residue 436 type sequence T description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 4) chain B residue 438 type sequence E description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 5) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 6) chain A residue 215 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 7) chain A residue 256 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 8) chain B residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 9) chain B residue 215 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 10) chain B residue 256 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 11) chain A residue 148 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 12) chain A residue 203 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 13) chain A residue 106 type sequence R description BINDING SITE FOR RESIDUE SO4 A 504 source : AC4 14) chain A residue 233 type sequence S description BINDING SITE FOR RESIDUE SO4 A 504 source : AC4 15) chain A residue 235 type sequence M description BINDING SITE FOR RESIDUE SO4 A 504 source : AC4 16) chain A residue 299 type sequence K description BINDING SITE FOR RESIDUE SO4 A 504 source : AC4 17) chain A residue 415 type sequence F description BINDING SITE FOR RESIDUE SO4 A 505 source : AC5 18) chain A residue 416 type sequence P description BINDING SITE FOR RESIDUE SO4 A 505 source : AC5 19) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE SO4 A 505 source : AC5 20) chain A residue 438 type sequence E description BINDING SITE FOR RESIDUE GOL B 501 source : AC6 21) chain B residue 430 type sequence H description BINDING SITE FOR RESIDUE GOL B 501 source : AC6 22) chain B residue 433 type sequence Q description BINDING SITE FOR RESIDUE GOL B 501 source : AC6 23) chain A residue 328 type sequence Q description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 24) chain A residue 332 type sequence D description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 25) chain B residue 11 type sequence F description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 26) chain B residue 38 type sequence S description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 27) chain B residue 39 type sequence E description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 28) chain B residue 198 type sequence K description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 29) chain B residue 205 type sequence F description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 30) chain B residue 148 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 31) chain B residue 203 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 32) chain B residue 316 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 33) chain B residue 106 type sequence R description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 34) chain B residue 233 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 35) chain B residue 299 type sequence K description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 36) chain B residue 373 type sequence S description BINDING SITE FOR RESIDUE SO4 B 505 source : BC1 37) chain B residue 374 type sequence D description BINDING SITE FOR RESIDUE SO4 B 505 source : BC1 38) chain A residue 373 type sequence S description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 39) chain A residue 374 type sequence D description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 40) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 41) chain B residue 216 type sequence K description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 42) chain A residue 338 type SITE sequence R description Important for interaction with ssb => ECO:0000305|PubMed:20018747 source Swiss-Prot : SWS_FT_FI7 43) chain B residue 338 type SITE sequence R description Important for interaction with ssb => ECO:0000305|PubMed:20018747 source Swiss-Prot : SWS_FT_FI7 44) chain A residue 15 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 15 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 17 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 165 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 165 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 186 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 17 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 18 type SITE sequence T description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 53) chain A residue 371 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 54) chain B residue 18 type SITE sequence T description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 66 type SITE sequence I description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 56) chain B residue 113 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 57) chain B residue 124 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 58) chain B residue 128 type SITE sequence W description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 142 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 60) chain B residue 214 type SITE sequence K description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 61) chain B residue 284 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 62) chain B residue 368 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 63) chain B residue 371 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 64) chain A residue 128 type SITE sequence W description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 142 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 66) chain A residue 214 type SITE sequence K description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 284 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 68) chain A residue 368 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 69) chain A residue 66 type SITE sequence I description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 70) chain A residue 113 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 71) chain A residue 124 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 72) chain A residue 148 type SITE sequence R description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 73) chain A residue 207 type SITE sequence Y description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 74) chain A residue 311 type SITE sequence Q description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 75) chain B residue 148 type SITE sequence R description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 76) chain B residue 207 type SITE sequence Y description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 311 type SITE sequence Q description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 78) chain B residue 164 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 79) chain B residue 257 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 80) chain B residue 304 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 81) chain A residue 164 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 82) chain A residue 257 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 83) chain A residue 304 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5

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