eF-site ID 4hcb-B PDB Code 4hcb Chain B click to enlarge Title The metal-free form of crystal structure of E.coli ExoI-ssDNA complex Classification HYDROLASE/DNA Compound Exodeoxyribonuclease I Source Escherichia coli (strain K12) (4HCB) Sequence B:  QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPE VFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAAR IHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWS WQHDNSRWDLLDVMRACYALRPEGINWPENLPSFRLEHLT KANGIEDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKH KLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPEN RNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAA VPVKLVHINKCPVLAQANTLRPEDADRLGINRQHCLDNLK ILRENPQVREKVVAIFAEAEPFTPSDNVDAQLYNGFFSDA DRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNF PGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYA DDKEKVALLKALWQYADEIVH Description Functional site 1) chain B residue 436 type sequence T description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 2) chain B residue 438 type sequence E description BINDING SITE FOR RESIDUE GOL A 501 source : AC1 3) chain B residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 4) chain B residue 215 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 5) chain B residue 256 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 6) chain B residue 430 type sequence H description BINDING SITE FOR RESIDUE GOL B 501 source : AC6 7) chain B residue 433 type sequence Q description BINDING SITE FOR RESIDUE GOL B 501 source : AC6 8) chain B residue 11 type sequence F description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 9) chain B residue 38 type sequence S description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 10) chain B residue 39 type sequence E description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 11) chain B residue 198 type sequence K description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 12) chain B residue 205 type sequence F description BINDING SITE FOR RESIDUE GOL B 502 source : AC7 13) chain B residue 148 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 14) chain B residue 203 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 15) chain B residue 316 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 16) chain B residue 106 type sequence R description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 17) chain B residue 233 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 18) chain B residue 299 type sequence K description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 19) chain B residue 373 type sequence S description BINDING SITE FOR RESIDUE SO4 B 505 source : BC1 20) chain B residue 374 type sequence D description BINDING SITE FOR RESIDUE SO4 B 505 source : BC1 21) chain B residue 211 type sequence H description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 22) chain B residue 216 type sequence K description BINDING SITE FOR RESIDUE SO4 B 506 source : BC2 23) chain B residue 338 type SITE sequence R description Important for interaction with ssb => ECO:0000305|PubMed:20018747 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 15 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 165 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 17 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 18 type SITE sequence T description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 66 type SITE sequence I description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 113 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 124 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 128 type SITE sequence W description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 142 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 214 type SITE sequence K description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 284 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 368 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 371 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 148 type SITE sequence R description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 207 type SITE sequence Y description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 311 type SITE sequence Q description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 164 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 42) chain B residue 257 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 43) chain B residue 304 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5

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