eF-site ID 4hb4-C PDB Code 4hb4 Chain C Title Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Classification PROTEIN TRANSPORT/ANTIBIOTIC Compound GTP-binding nuclear protein Ran Source Homo sapiens (Human) (XPO1_YEAST) Sequence C:  GAMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEIL TKFQDNPDAWQKADQILQFSTNPQSKFIALSILDKLITRK WKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKS DLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIV LKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELL STKFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLF FQNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMF LTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEEREL FKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM VRPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYL THLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSI SGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDI MYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMA CDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTAD LQPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMA WDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGA DFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPK VRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAV LEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQ SVFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFL ELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNI ERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQ ALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYL ANMLSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDF LVQIKEVGGDPTDYLFA Description (1)  GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1 Functional site 1) chain C residue 525 type sequence K description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 2) chain C residue 539 type sequence C description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 3) chain C residue 540 type sequence E description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 4) chain C residue 548 type sequence K description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 5) chain C residue 552 type sequence A description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 6) chain C residue 569 type sequence H description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 7) chain C residue 572 type sequence F description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 8) chain C residue 575 type sequence T description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 9) chain C residue 579 type sequence K description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 10) chain C residue 583 type sequence F description BINDING SITE FOR RESIDUE LMB C 1101 source : AC4 11) chain C residue 842 type sequence L description BINDING SITE FOR RESIDUE GOL C 1102 source : AC5 12) chain C residue 846 type sequence N description BINDING SITE FOR RESIDUE GOL C 1102 source : AC5 13) chain C residue 891 type sequence W description BINDING SITE FOR RESIDUE GOL C 1102 source : AC5 14) chain C residue 967 type sequence Y description BINDING SITE FOR RESIDUE EDO C 1103 source : AC6 15) chain C residue 988 type sequence Q description BINDING SITE FOR RESIDUE EDO C 1103 source : AC6 16) chain C residue 992 type sequence S description BINDING SITE FOR RESIDUE EDO C 1103 source : AC6 17) chain C residue 1009 type sequence E description BINDING SITE FOR RESIDUE CL C 1104 source : AC7 18) chain C residue 605 type sequence K description BINDING SITE FOR RESIDUE CL C 1105 source : AC8 19) chain C residue 608 type sequence Y description BINDING SITE FOR RESIDUE CL C 1105 source : AC8 20) chain C residue 61 type sequence P description BINDING SITE FOR RESIDUE CL C 1106 source : AC9 21) chain C residue 62 type sequence Q description BINDING SITE FOR RESIDUE CL C 1106 source : AC9 22) chain C residue 227 type sequence R description BINDING SITE FOR RESIDUE CL C 1107 source : BC1

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