eF-site ID 4hau-C
PDB Code 4hau
Chain C

click to enlarge
Title Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1
Classification PROTEIN TRANSPORT/ANTIBIOTIC
Compound GTP-binding nuclear protein Ran
Source Homo sapiens (Human) (XPO1_YEAST)
Sequence C:  GAMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEIL
TKFQDNPDAWQKADQILQFSTNPQSKFIALSILDKLITRK
WKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKS
DLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIV
LKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSLIVATLESLLRYLHWIPYRYIYETNILELLS
TKFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFF
QNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFL
TTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELF
KTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV
RPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLT
HLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSIS
GTMSEDTEKRFVVTVIKDLLDLCVKKRGKDNKAVVASDIM
YVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMAC
DTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADL
QPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAW
DTIVEQSTANPLLLDSETVKIIANIIKTNVAVCTSMGADF
YPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVR
GLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLE
DYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSV
FECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLEL
PPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIER
MGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQAL
LLMKLISLVYDNKISVPLYQAEVPQGTSNQVYLSQYLANM
LSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQ
IKEVGGDPTDYLFA
Description (1)  GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1


Functional site

1) chain C
residue 532
type
sequence I
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

2) chain C
residue 533
type
sequence K
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

3) chain C
residue 536
type
sequence L
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

4) chain C
residue 539
type
sequence C
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

5) chain C
residue 552
type
sequence A
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

6) chain C
residue 555
type
sequence I
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

7) chain C
residue 569
type
sequence H
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

8) chain C
residue 572
type
sequence F
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

9) chain C
residue 575
type
sequence T
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

10) chain C
residue 579
type
sequence K
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

11) chain C
residue 583
type
sequence F
description BINDING SITE FOR RESIDUE RJA C 1101
source : AC5

12) chain C
residue 191
type
sequence E
description BINDING SITE FOR RESIDUE GOL C 1102
source : AC6

13) chain C
residue 227
type
sequence R
description BINDING SITE FOR RESIDUE GOL C 1102
source : AC6

14) chain C
residue 231
type
sequence E
description BINDING SITE FOR RESIDUE GOL C 1102
source : AC6

15) chain C
residue 164
type
sequence E
description BINDING SITE FOR RESIDUE GOL C 1103
source : AC7

16) chain C
residue 219
type
sequence R
description BINDING SITE FOR RESIDUE GOL C 1103
source : AC7

17) chain C
residue 842
type
sequence L
description BINDING SITE FOR RESIDUE GOL C 1104
source : AC8

18) chain C
residue 846
type
sequence N
description BINDING SITE FOR RESIDUE GOL C 1104
source : AC8

19) chain C
residue 891
type
sequence W
description BINDING SITE FOR RESIDUE GOL C 1104
source : AC8

20) chain C
residue 327
type
sequence R
description BINDING SITE FOR RESIDUE EDO C 1105
source : AC9

21) chain C
residue 328
type
sequence A
description BINDING SITE FOR RESIDUE EDO C 1105
source : AC9

22) chain C
residue 331
type
sequence E
description BINDING SITE FOR RESIDUE EDO C 1105
source : AC9

23) chain C
residue 372
type
sequence D
description BINDING SITE FOR RESIDUE EDO C 1105
source : AC9

24) chain C
residue 416
type
sequence K
description BINDING SITE FOR RESIDUE EDO C 1105
source : AC9

25) chain C
residue 967
type
sequence Y
description BINDING SITE FOR RESIDUE EDO C 1106
source : BC1

26) chain C
residue 988
type
sequence Q
description BINDING SITE FOR RESIDUE EDO C 1106
source : BC1

27) chain C
residue 992
type
sequence S
description BINDING SITE FOR RESIDUE EDO C 1106
source : BC1

28) chain C
residue 1019
type
sequence T
description BINDING SITE FOR RESIDUE EDO C 1106
source : BC1

29) chain C
residue 1007
type
sequence T
description BINDING SITE FOR RESIDUE CL C 1107
source : BC2

30) chain C
residue 1008
type
sequence S
description BINDING SITE FOR RESIDUE CL C 1107
source : BC2

31) chain C
residue 1009
type
sequence E
description BINDING SITE FOR RESIDUE CL C 1107
source : BC2

32) chain C
residue 605
type
sequence K
description BINDING SITE FOR RESIDUE CL C 1108
source : BC3

33) chain C
residue 606
type
sequence C
description BINDING SITE FOR RESIDUE CL C 1108
source : BC3

34) chain C
residue 607
type
sequence K
description BINDING SITE FOR RESIDUE CL C 1108
source : BC3

35) chain C
residue 608
type
sequence Y
description BINDING SITE FOR RESIDUE CL C 1108
source : BC3

36) chain C
residue 61
type
sequence P
description BINDING SITE FOR RESIDUE CL C 1109
source : BC4

37) chain C
residue 62
type
sequence Q
description BINDING SITE FOR RESIDUE CL C 1109
source : BC4


Display surface

Download
Links