eF-site ID 4hau-C PDB Code 4hau Chain C click to enlarge Title Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1 Classification PROTEIN TRANSPORT/ANTIBIOTIC Compound GTP-binding nuclear protein Ran Source Homo sapiens (Human) (XPO1_YEAST) Sequence C:  GAMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEIL TKFQDNPDAWQKADQILQFSTNPQSKFIALSILDKLITRK WKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKS DLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIV LKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF QVLEQGSSSLIVATLESLLRYLHWIPYRYIYETNILELLS TKFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFF QNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFL TTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELF KTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV RPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLT HLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSIS GTMSEDTEKRFVVTVIKDLLDLCVKKRGKDNKAVVASDIM YVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMAC DTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADL QPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAW DTIVEQSTANPLLLDSETVKIIANIIKTNVAVCTSMGADF YPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVR GLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLE DYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSV FECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLEL PPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIER MGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQAL LLMKLISLVYDNKISVPLYQAEVPQGTSNQVYLSQYLANM LSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQ IKEVGGDPTDYLFA Description (1)  GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1 Functional site 1) chain C residue 532 type sequence I description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 2) chain C residue 533 type sequence K description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 3) chain C residue 536 type sequence L description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 4) chain C residue 539 type sequence C description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 5) chain C residue 552 type sequence A description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 6) chain C residue 555 type sequence I description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 7) chain C residue 569 type sequence H description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 8) chain C residue 572 type sequence F description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 9) chain C residue 575 type sequence T description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 10) chain C residue 579 type sequence K description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 11) chain C residue 583 type sequence F description BINDING SITE FOR RESIDUE RJA C 1101 source : AC5 12) chain C residue 191 type sequence E description BINDING SITE FOR RESIDUE GOL C 1102 source : AC6 13) chain C residue 227 type sequence R description BINDING SITE FOR RESIDUE GOL C 1102 source : AC6 14) chain C residue 231 type sequence E description BINDING SITE FOR RESIDUE GOL C 1102 source : AC6 15) chain C residue 164 type sequence E description BINDING SITE FOR RESIDUE GOL C 1103 source : AC7 16) chain C residue 219 type sequence R description BINDING SITE FOR RESIDUE GOL C 1103 source : AC7 17) chain C residue 842 type sequence L description BINDING SITE FOR RESIDUE GOL C 1104 source : AC8 18) chain C residue 846 type sequence N description BINDING SITE FOR RESIDUE GOL C 1104 source : AC8 19) chain C residue 891 type sequence W description BINDING SITE FOR RESIDUE GOL C 1104 source : AC8 20) chain C residue 327 type sequence R description BINDING SITE FOR RESIDUE EDO C 1105 source : AC9 21) chain C residue 328 type sequence A description BINDING SITE FOR RESIDUE EDO C 1105 source : AC9 22) chain C residue 331 type sequence E description BINDING SITE FOR RESIDUE EDO C 1105 source : AC9 23) chain C residue 372 type sequence D description BINDING SITE FOR RESIDUE EDO C 1105 source : AC9 24) chain C residue 416 type sequence K description BINDING SITE FOR RESIDUE EDO C 1105 source : AC9 25) chain C residue 967 type sequence Y description BINDING SITE FOR RESIDUE EDO C 1106 source : BC1 26) chain C residue 988 type sequence Q description BINDING SITE FOR RESIDUE EDO C 1106 source : BC1 27) chain C residue 992 type sequence S description BINDING SITE FOR RESIDUE EDO C 1106 source : BC1 28) chain C residue 1019 type sequence T description BINDING SITE FOR RESIDUE EDO C 1106 source : BC1 29) chain C residue 1007 type sequence T description BINDING SITE FOR RESIDUE CL C 1107 source : BC2 30) chain C residue 1008 type sequence S description BINDING SITE FOR RESIDUE CL C 1107 source : BC2 31) chain C residue 1009 type sequence E description BINDING SITE FOR RESIDUE CL C 1107 source : BC2 32) chain C residue 605 type sequence K description BINDING SITE FOR RESIDUE CL C 1108 source : BC3 33) chain C residue 606 type sequence C description BINDING SITE FOR RESIDUE CL C 1108 source : BC3 34) chain C residue 607 type sequence K description BINDING SITE FOR RESIDUE CL C 1108 source : BC3 35) chain C residue 608 type sequence Y description BINDING SITE FOR RESIDUE CL C 1108 source : BC3 36) chain C residue 61 type sequence P description BINDING SITE FOR RESIDUE CL C 1109 source : BC4 37) chain C residue 62 type sequence Q description BINDING SITE FOR RESIDUE CL C 1109 source : BC4

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