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eF-site ID
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4h4o-B |
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PDB Code
|
4h4o |
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Chain
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B |
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click to enlarge
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Title
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Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor |
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Classification
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Hydrolase/Hydrolase inhibitor |
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Compound
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Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) |
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Sequence
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B: |
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQ
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Description
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Functional site
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1)
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chain |
B |
| residue |
401 |
| type |
SITE |
| sequence |
W
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| description |
Essential for RT p66/p51 heterodimerization
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| source |
Swiss-Prot : SWS_FT_FI2
|
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2)
|
chain |
B |
| residue |
414 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization
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| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
B |
| residue |
110 |
| type |
BINDING |
| sequence |
D
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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4)
|
chain |
B |
| residue |
185 |
| type |
BINDING |
| sequence |
D
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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5)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
D
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
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