eF-site ID 4h3h-ABDEF PDB Code 4h3h Chain A, B, D, E, F click to enlarge Title Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7 Classification HYDROLASE Compound Symplekin Source Homo sapiens (Human) (4H3H) Sequence A:  VPRGSHMTTSERVVDLLNQAALITNDSKITVLKQVQELII NKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRD IELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQW MVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHA IKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYI QYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANI ARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKL HLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMP B:  LRVAVVSSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLP GPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHML DRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNS REQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHT EDMENEIDELLQEFEEKSGRTFLHTVCFY D:  MTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTL LDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLK LIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRV ISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEG LIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLW EEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPM FMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVL KHPASLEFQAQITTLLVDLGTPQAEIARNMP E:  SSPLRVAVVSSSNQNRSMEAHNILSKRGFSVRSFGTGTHV KLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGIL HMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVED LNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCI QHTEDMENEIDELLQEFEEKSGRTFLHTVCFY F:  PTSPXYSP Description (1)  Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (E.C.3.1.3.16), Pol II CTD peptide Functional site 1) chain B residue 12 type sequence S description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 2) chain B residue 13 type sequence S description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 3) chain B residue 14 type sequence S description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 4) chain B residue 15 type sequence N description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 5) chain B residue 16 type sequence Q description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 6) chain B residue 17 type sequence N description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 7) chain B residue 18 type sequence R description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 8) chain B residue 143 type sequence D description BINDING SITE FOR RESIDUE PO4 B 201 source : AC1 9) chain B residue 179-186 type prosite sequence FEEKSGRT description CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FeEkSGRT source prosite : PS00097

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