Title
|
Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7 |
Classification
|
HYDROLASE |
Compound
|
Symplekin |
Source
|
Homo sapiens (Human) (4H3H) |
|
Sequence
|
A: |
VPRGSHMTTSERVVDLLNQAALITNDSKITVLKQVQELII
NKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRD
IELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQW
MVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHA
IKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYI
QYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANI
ARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKL
HLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMP
|
B: |
LRVAVVSSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLP
GPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHML
DRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNS
REQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHT
EDMENEIDELLQEFEEKSGRTFLHTVCFY
|
D: |
MTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTL
LDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLK
LIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRV
ISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEG
LIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLW
EEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPM
FMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVL
KHPASLEFQAQITTLLVDLGTPQAEIARNMP
|
E: |
SSPLRVAVVSSSNQNRSMEAHNILSKRGFSVRSFGTGTHV
KLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGIL
HMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVED
LNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCI
QHTEDMENEIDELLQEFEEKSGRTFLHTVCFY
|
F: |
PTSPXYSP
|
|
Description
|
(1) |
Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (E.C.3.1.3.16), Pol II CTD peptide
|