|
eF-site ID
|
4gv3-AC |
PDB Code
|
4gv3 |
Chain
|
A, C |
|
click to enlarge
|
|
Title
|
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production |
Classification
|
RNA BINDING PROTEIN/RNA |
Compound
|
RNA (5'-R(*(GTP)P*GP*GP*C)-3') |
Source
|
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) (4GV3) |
|
Sequence
|
A: |
GAMDHVEFGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPE
DPVEIALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDV
TDLFATQPGLTSAVIDALPRNMVITCQGSDDIRKLLESQG
RKDIKLIDIALSKTDSRKYENAVWDQYKDLCHMHTGVVVE
KEEITPHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFR
TSPRVVL
|
C: |
GCCC
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
389 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MN B 101
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
399 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE ZN A 601
|
source |
: AC2
|
|
3)
|
chain |
A |
residue |
506 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 601
|
source |
: AC2
|
|
4)
|
chain |
A |
residue |
509 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 601
|
source |
: AC2
|
|
5)
|
chain |
A |
residue |
529 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 601
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
389 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
7)
|
chain |
A |
residue |
391 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
8)
|
chain |
A |
residue |
533 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
9)
|
chain |
A |
residue |
529 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
10)
|
chain |
A |
residue |
399 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
11)
|
chain |
A |
residue |
506 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
12)
|
chain |
A |
residue |
509 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
13)
|
chain |
A |
residue |
466 |
type |
SITE |
sequence |
D
|
description |
Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|