eF-site ID 4gt4-B
PDB Code 4gt4
Chain B

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Title Structure of unliganded, inactive Ror2 kinase domain
Classification TRANSFERASE
Compound Tyrosine-protein kinase transmembrane receptor ROR2
Source Homo sapiens (Human) (ROR2_HUMAN)
Sequence B:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK
DKAEPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM
IFSYCSHGDLHEFLVMRSPHSRTVKSALEPPDFVHLVAQI
AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE
VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG
VVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA
WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNL
Description (1)  Tyrosine-protein kinase transmembrane receptor ROR2 (E.C.2.7.10.1)


Functional site

1) chain B
residue 557
type
sequence S
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

2) chain B
residue 558
type
sequence H
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

3) chain B
residue 624
type
sequence Y
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

4) chain B
residue 625
type
sequence D
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

5) chain B
residue 592
type
sequence F
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

6) chain B
residue 686
type
sequence F
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

7) chain B
residue 688
type
sequence Y
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

8) chain B
residue 716
type
sequence D
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

9) chain B
residue 615
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

10) chain B
residue 479
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

11) chain B
residue 507
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

12) chain B
residue 469
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

13) chain B
residue 471
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

14) chain B
residue 646
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI4


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