eF-site ID 4gt4-B PDB Code 4gt4 Chain B click to enlarge Title Structure of unliganded, inactive Ror2 kinase domain Classification TRANSFERASE Compound Tyrosine-protein kinase transmembrane receptor ROR2 Source Homo sapiens (Human) (ROR2_HUMAN) Sequence B:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK DKAEPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM IFSYCSHGDLHEFLVMRSPHSRTVKSALEPPDFVHLVAQI AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG VVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNL Description (1)  Tyrosine-protein kinase transmembrane receptor ROR2 (E.C.2.7.10.1) Functional site 1) chain B residue 557 type sequence S description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 2) chain B residue 558 type sequence H description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 3) chain B residue 624 type sequence Y description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 4) chain B residue 625 type sequence D description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 5) chain B residue 592 type sequence F description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 6) chain B residue 686 type sequence F description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 7) chain B residue 688 type sequence Y description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 8) chain B residue 716 type sequence D description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 9) chain B residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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