eF-site ID 4gt4-AB PDB Code 4gt4 Chain A, B click to enlarge Title Structure of unliganded, inactive Ror2 kinase domain Classification TRANSFERASE Compound Tyrosine-protein kinase transmembrane receptor ROR2 Source Homo sapiens (Human) (ROR2_HUMAN) Sequence A:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK DAEGLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMI FSYCSHGDLHEFLVMRSPHSDVGRTVKSALEPPDFVHLVA QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLF REVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWS YGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC PAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGN B:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK DKAEPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM IFSYCSHGDLHEFLVMRSPHSRTVKSALEPPDFVHLVAQI AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG VVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNL Description (1)  Tyrosine-protein kinase transmembrane receptor ROR2 (E.C.2.7.10.1) Functional site 1) chain A residue 607 type sequence S description BINDING SITE FOR RESIDUE NO3 A 801 source : AC1 2) chain A residue 735 type sequence R description BINDING SITE FOR RESIDUE NO3 A 801 source : AC1 3) chain A residue 738 type sequence R description BINDING SITE FOR RESIDUE NO3 A 801 source : AC1 4) chain A residue 739 type sequence F description BINDING SITE FOR RESIDUE NO3 A 801 source : AC1 5) chain A residue 740 type sequence K description BINDING SITE FOR RESIDUE NO3 A 801 source : AC1 6) chain A residue 592 type sequence F description BINDING SITE FOR RESIDUE NO3 A 802 source : AC2 7) chain A residue 688 type sequence Y description BINDING SITE FOR RESIDUE NO3 A 802 source : AC2 8) chain A residue 716 type sequence D description BINDING SITE FOR RESIDUE NO3 A 802 source : AC2 9) chain B residue 557 type sequence S description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 10) chain B residue 558 type sequence H description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 11) chain B residue 624 type sequence Y description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 12) chain B residue 625 type sequence D description BINDING SITE FOR RESIDUE NO3 B 801 source : AC3 13) chain B residue 592 type sequence F description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 14) chain B residue 686 type sequence F description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 15) chain B residue 688 type sequence Y description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 16) chain B residue 716 type sequence D description BINDING SITE FOR RESIDUE NO3 B 802 source : AC4 17) chain A residue 611-623 type prosite sequence VVHKDLATRNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VVHkDLATRNVLV source prosite : PS00109 18) chain A residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 26) chain B residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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