eF-site ID 4gt4-AB
PDB Code 4gt4
Chain A, B

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Title Structure of unliganded, inactive Ror2 kinase domain
Classification TRANSFERASE
Compound Tyrosine-protein kinase transmembrane receptor ROR2
Source Homo sapiens (Human) (ROR2_HUMAN)
Sequence A:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK
DAEGLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMI
FSYCSHGDLHEFLVMRSPHSDVGRTVKSALEPPDFVHLVA
QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLF
REVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWS
YGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC
PAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGN
B:  KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLK
DKAEPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM
IFSYCSHGDLHEFLVMRSPHSRTVKSALEPPDFVHLVAQI
AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE
VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG
VVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA
WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNL
Description (1)  Tyrosine-protein kinase transmembrane receptor ROR2 (E.C.2.7.10.1)


Functional site

1) chain A
residue 607
type
sequence S
description BINDING SITE FOR RESIDUE NO3 A 801
source : AC1

2) chain A
residue 735
type
sequence R
description BINDING SITE FOR RESIDUE NO3 A 801
source : AC1

3) chain A
residue 738
type
sequence R
description BINDING SITE FOR RESIDUE NO3 A 801
source : AC1

4) chain A
residue 739
type
sequence F
description BINDING SITE FOR RESIDUE NO3 A 801
source : AC1

5) chain A
residue 740
type
sequence K
description BINDING SITE FOR RESIDUE NO3 A 801
source : AC1

6) chain A
residue 592
type
sequence F
description BINDING SITE FOR RESIDUE NO3 A 802
source : AC2

7) chain A
residue 688
type
sequence Y
description BINDING SITE FOR RESIDUE NO3 A 802
source : AC2

8) chain A
residue 716
type
sequence D
description BINDING SITE FOR RESIDUE NO3 A 802
source : AC2

9) chain B
residue 557
type
sequence S
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

10) chain B
residue 558
type
sequence H
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

11) chain B
residue 624
type
sequence Y
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

12) chain B
residue 625
type
sequence D
description BINDING SITE FOR RESIDUE NO3 B 801
source : AC3

13) chain B
residue 592
type
sequence F
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

14) chain B
residue 686
type
sequence F
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

15) chain B
residue 688
type
sequence Y
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

16) chain B
residue 716
type
sequence D
description BINDING SITE FOR RESIDUE NO3 B 802
source : AC4

17) chain A
residue 611-623
type prosite
sequence VVHKDLATRNVLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VVHkDLATRNVLV
source prosite : PS00109

18) chain A
residue 615
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

19) chain B
residue 615
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 479
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 507
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

22) chain B
residue 479
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

23) chain B
residue 507
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 469
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

25) chain A
residue 471
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

26) chain B
residue 469
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

27) chain B
residue 471
type MOD_RES
sequence S
description Sulfoserine; partial => ECO:0000269|PubMed:14752058
source Swiss-Prot : SWS_FT_FI3

28) chain A
residue 646
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

29) chain B
residue 646
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000250
source Swiss-Prot : SWS_FT_FI4


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