eF-site ID 4gsu-B PDB Code 4gsu Chain B click to enlarge Title Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains Classification TRANSFERASE Compound Probable conserved lipoprotein LPPS Source Mycobacterium tuberculosis (O53223_MYCTU) Sequence B:  LTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIAD RGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGT AVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDN TKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKH IIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPW SVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNT VGGTLPGIDGLGDWNIPWDQWRAGNAKA Description Functional site 1) chain B residue 303 type sequence M description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 2) chain B residue 308 type sequence Y description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 3) chain B residue 318 type sequence Y description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 4) chain B residue 332 type sequence G description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 5) chain B residue 352 type sequence H description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 6) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 7) chain B residue 354 type sequence C description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 8) chain B residue 354 type SITE sequence C description Binds to carbapenem drug (covalent) => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 9) chain B residue 232 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 235 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 236 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 318 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI4 13) chain B residue 331 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI4 14) chain B residue 356 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 15) chain B residue 336 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 354 type ACT_SITE sequence C description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390 source Swiss-Prot : SWS_FT_FI2

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