eF-site ID 4gsu-AB PDB Code 4gsu Chain A, B click to enlarge Title Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains Classification TRANSFERASE Compound Probable conserved lipoprotein LPPS Source Mycobacterium tuberculosis (O53223_MYCTU) Sequence A:  LTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIAD RGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGT AVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDN TKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKH IIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPW SVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNT VGGTLPGIDGLGDWNIPWDQWRAGNAKA B:  LTFQTSSPAHLTMPYVMPGDGEVVGVGEPVAIRFDENIAD RGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGT AVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDN TKILTVRVNGEVVKSMPTSMGKDSTPTANGIYIVGSRYKH IIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPW SVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNT VGGTLPGIDGLGDWNIPWDQWRAGNAKA Description Functional site 1) chain A residue 303 type sequence M description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 2) chain A residue 308 type sequence Y description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 3) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 4) chain A residue 333 type sequence V description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 5) chain A residue 352 type sequence H description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 6) chain A residue 353 type sequence G description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 7) chain A residue 354 type sequence C description BINDING SITE FOR RESIDUE DWZ A 501 source : AC1 8) chain A residue 145 type sequence T description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 9) chain B residue 303 type sequence M description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 10) chain B residue 308 type sequence Y description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 11) chain B residue 318 type sequence Y description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 12) chain B residue 332 type sequence G description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 13) chain B residue 352 type sequence H description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 14) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 15) chain B residue 354 type sequence C description BINDING SITE FOR RESIDUE DWZ B 501 source : AC2 16) chain A residue 354 type SITE sequence C description Binds to carbapenem drug (covalent) => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 354 type SITE sequence C description Binds to carbapenem drug (covalent) => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 232 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 235 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 236 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 232 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 235 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 236 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 318 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI4 25) chain A residue 331 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI4 26) chain A residue 356 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 27) chain B residue 318 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI4 28) chain B residue 331 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI4 29) chain B residue 356 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI4 30) chain A residue 336 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 336 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 354 type ACT_SITE sequence C description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 354 type ACT_SITE sequence C description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390 source Swiss-Prot : SWS_FT_FI2

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