eF-site ID 4grt-A PDB Code 4grt Chain A click to enlarge Title HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME Classification OXIDOREDUCTASE Compound GLUTATHIONE REDUCTASE Source Homo sapiens (Human) (GSHR_HUMAN) Sequence A:  VASYDYLVIGGGSGGLESAWRAAELGARAAVVESHKLGGT CVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWR VIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITS DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMI RHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKD LSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL LTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKC VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATK ADFDNTVAIHPTSSEELVTLR Description Functional site 1) chain A residue 467 type sequence H description THE ACTIVE SITE HISTIDINE (HIS 467) IS FROM THE OTHER SUBUNIT. source : S1 2) chain A residue 26 type sequence I description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 4) chain A residue 28 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 5) chain A residue 29 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 6) chain A residue 30 type sequence S description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 7) chain A residue 31 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 8) chain A residue 49 type sequence V description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 9) chain A residue 50 type sequence E description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 10) chain A residue 51 type sequence S description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 11) chain A residue 52 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 12) chain A residue 53 type sequence K description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 13) chain A residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 14) chain A residue 57 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 15) chain A residue 61 type sequence V description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 16) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 17) chain A residue 63 type sequence C description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 18) chain A residue 66 type sequence K description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 19) chain A residue 128 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 20) chain A residue 129 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 21) chain A residue 130 type sequence A description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 22) chain A residue 156 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 23) chain A residue 157 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 24) chain A residue 158 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 25) chain A residue 197 type sequence Y description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 26) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 27) chain A residue 331 type sequence D description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 28) chain A residue 337 type sequence L description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 29) chain A residue 338 type sequence L description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 30) chain A residue 339 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 31) chain A residue 340 type sequence P description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 32) chain A residue 342 type sequence A description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 33) chain A residue 467 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC1 34) chain A residue 30 type sequence S description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 35) chain A residue 33 type sequence L description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 36) chain A residue 34 type sequence E description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 37) chain A residue 58 type sequence C description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 38) chain A residue 59 type sequence V description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 39) chain A residue 64 type sequence V description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 40) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 41) chain A residue 114 type sequence Y description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 42) chain A residue 339 type sequence T description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 43) chain A residue 343 type sequence I description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 44) chain A residue 406 type sequence M description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 45) chain A residue 467 type sequence H description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 46) chain A residue 469 type sequence T description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 47) chain A residue 472 type sequence E description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 48) chain A residue 473 type sequence E description BINDING SITE FOR RESIDUE GCG A 17 source : AC2 49) chain A residue 102 type catalytic sequence K description 6 source MCSA : MCSA1 50) chain A residue 107 type catalytic sequence V description 6 source MCSA : MCSA1 51) chain A residue 110 type catalytic sequence L description 6 source MCSA : MCSA1 52) chain A residue 241 type catalytic sequence A description 6 source MCSA : MCSA1 53) chain A residue 245 type catalytic sequence V description 6 source MCSA : MCSA1 54) chain A residue 97 type MOD_RES sequence R description N6-acetyllysine => ECO:0000250|UniProtKB:P47791 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 94 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 56) chain A residue 55-65 type prosite sequence GGTCVNVGCVP description PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP source prosite : PS00076

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