eF-site ID 4gr1-A PDB Code 4gr1 Chain A click to enlarge Title THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE Classification OXIDOREDUCTASE (FLAVOENZYME) Compound GLUTATHIONE REDUCTASE Source Homo sapiens (Human) (GSHR_HUMAN) Sequence A:  VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGT CVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWR VIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITS DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMI RHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKD LSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL LTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKC VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATK ADFDNTVAIHPTSSEELVTLR Description (1)  GLUTATHIONE REDUCTASE (E.C.1.6.4.2) OXIDIZED FORM COMPLEXED WITH RETRO-GSSG Functional site 1) chain A residue 219 type sequence H description BINDING SITE FOR RESIDUE PO4 A 480 source : AC1 2) chain A residue 224 type sequence R description BINDING SITE FOR RESIDUE PO4 A 480 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 4) chain A residue 29 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 5) chain A residue 30 type sequence S description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 6) chain A residue 31 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 7) chain A residue 50 type sequence E description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 8) chain A residue 51 type sequence S description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 9) chain A residue 52 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 10) chain A residue 56 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 11) chain A residue 57 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 12) chain A residue 58 type sequence C description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 13) chain A residue 61 type sequence V description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 14) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 15) chain A residue 63 type sequence C description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 16) chain A residue 66 type sequence K description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 17) chain A residue 128 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 18) chain A residue 129 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 19) chain A residue 130 type sequence A description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 20) chain A residue 155 type sequence A description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 21) chain A residue 156 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 22) chain A residue 157 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 23) chain A residue 197 type sequence Y description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 24) chain A residue 291 type sequence R description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 25) chain A residue 298 type sequence L description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 26) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 27) chain A residue 331 type sequence D description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 28) chain A residue 337 type sequence L description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 29) chain A residue 338 type sequence L description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 30) chain A residue 339 type sequence T description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 31) chain A residue 340 type sequence P description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 32) chain A residue 467 type sequence H description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 33) chain A residue 468 type sequence P description BINDING SITE FOR RESIDUE FAD A 479 source : AC2 34) chain A residue 58 type sequence C description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 35) chain A residue 64 type sequence V description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 36) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 37) chain A residue 114 type sequence Y description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 38) chain A residue 347 type sequence R description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 39) chain A residue 403 type sequence F description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 40) chain A residue 406 type sequence M description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 41) chain A residue 467 type sequence H description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 42) chain A residue 468 type sequence P description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 43) chain A residue 469 type sequence T description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 44) chain A residue 472 type sequence E description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 45) chain A residue 473 type sequence E description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 46) chain A residue 476 type sequence T description BINDING SITE FOR RESIDUE RGS A 481 source : AC3 47) chain A residue 102 type catalytic sequence K description 6 source MCSA : MCSA1 48) chain A residue 107 type catalytic sequence V description 6 source MCSA : MCSA1 49) chain A residue 110 type catalytic sequence L description 6 source MCSA : MCSA1 50) chain A residue 241 type catalytic sequence A description 6 source MCSA : MCSA1 51) chain A residue 245 type catalytic sequence V description 6 source MCSA : MCSA1 52) chain A residue 97 type MOD_RES sequence R description N6-acetyllysine => ECO:0000250|UniProtKB:P47791 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 94 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 54) chain A residue 55-65 type prosite sequence GGTCVNVGCVP description PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP source prosite : PS00076

Display surface Download Links