eF-site ID 4gqs-D PDB Code 4gqs Chain D click to enlarge Title Structure of Human Microsomal Cytochrome P450 (CYP) 2C19 Classification OXIDOREDUCTASE Compound Cytochrome P450 2C19 Source Homo sapiens (Human) (CP2CJ_HUMAN) Sequence D:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLEDRVQEEARCLVEELRK TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLA FMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFAS VPPFYQLCFIPI Description Functional site 1) chain D residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 2) chain D residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 3) chain D residue 113 type sequence V description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 4) chain D residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 5) chain D residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 6) chain D residue 294 type sequence L description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 7) chain D residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 8) chain D residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 9) chain D residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 10) chain D residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 11) chain D residue 356 type sequence Q description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 12) chain D residue 362 type sequence I description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 13) chain D residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 14) chain D residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 15) chain D residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 16) chain D residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 17) chain D residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 18) chain D residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 19) chain D residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 20) chain D residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 21) chain D residue 205 type sequence I description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 22) chain D residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 23) chain D residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 24) chain D residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 25) chain D residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 26) chain D residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 27) chain D residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1

Display surface Download Links