eF-site ID 4gqs-C PDB Code 4gqs Chain C click to enlarge Title Structure of Human Microsomal Cytochrome P450 (CYP) 2C19 Classification OXIDOREDUCTASE Compound Cytochrome P450 2C19 Source Homo sapiens (Human) (CP2CJ_HUMAN) Sequence C:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFL IKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTIL TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD TTPVVNGFASVPPFYQLCFIPI Description Functional site 1) chain C residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 2) chain C residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 3) chain C residue 113 type sequence V description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 4) chain C residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 5) chain C residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 6) chain C residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 7) chain C residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 8) chain C residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 9) chain C residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 10) chain C residue 305 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 11) chain C residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 12) chain C residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 13) chain C residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 14) chain C residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 15) chain C residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 16) chain C residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 17) chain C residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 18) chain C residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 19) chain C residue 437 type sequence G description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 20) chain C residue 114 type sequence F description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 21) chain C residue 205 type sequence I description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 22) chain C residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 23) chain C residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 24) chain C residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 25) chain C residue 301 type sequence T description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 26) chain C residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 27) chain C residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 28) chain C residue 476 type sequence F description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 29) chain C residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1

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