eF-site ID 4gqs-B PDB Code 4gqs Chain B click to enlarge Title Structure of Human Microsomal Cytochrome P450 (CYP) 2C19 Classification OXIDOREDUCTASE Compound Cytochrome P450 2C19 Source Homo sapiens (Human) (CP2CJ_HUMAN) Sequence B:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD YKDQQFLNLMEKLNENIRIVSTPWIQICNNYFPGTHNKLL KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLL KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHE VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI CVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVN GFASVPPFYQLCFIPI Description Functional site 1) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 2) chain B residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 3) chain B residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 4) chain B residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 5) chain B residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 6) chain B residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 7) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 8) chain B residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 9) chain B residue 305 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 10) chain B residue 362 type sequence I description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 11) chain B residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 12) chain B residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 13) chain B residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 14) chain B residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 15) chain B residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 16) chain B residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 17) chain B residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 18) chain B residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 19) chain B residue 437 type sequence G description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 20) chain B residue 441 type sequence A description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 21) chain B residue 113 type sequence V description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 22) chain B residue 114 type sequence F description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 23) chain B residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 24) chain B residue 296 type sequence G description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 25) chain B residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 26) chain B residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 27) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 28) chain B residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 29) chain B residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 30) chain B residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1

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