eF-site ID 4gqs-ABCD PDB Code 4gqs Chain A, B, C, D click to enlarge Title Structure of Human Microsomal Cytochrome P450 (CYP) 2C19 Classification OXIDOREDUCTASE Compound Cytochrome P450 2C19 Source Homo sapiens (Human) (CP2CJ_HUMAN) Sequence A:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFL IKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTIL TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD TTPVVNGFASVPPFYQLCFIPIHH B:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD YKDQQFLNLMEKLNENIRIVSTPWIQICNNYFPGTHNKLL KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLL KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHE VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI CVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVN GFASVPPFYQLCFIPI C:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFL IKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTIL TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD TTPVVNGFASVPPFYQLCFIPI D:  LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLY FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR GFGIVFSNGKRWKEIRRFSLMTLEDRVQEEARCLVEELRK TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLA FMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFAS VPPFYQLCFIPI Description Functional site 1) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 2) chain A residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 3) chain A residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 4) chain A residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 5) chain A residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 6) chain A residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 7) chain A residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 8) chain A residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 9) chain A residue 305 type sequence T description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 10) chain A residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 11) chain A residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 12) chain A residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 13) chain A residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 14) chain A residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 15) chain A residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 16) chain A residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 17) chain A residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 18) chain A residue 437 type sequence G description BINDING SITE FOR RESIDUE HEM A 501 source : AC1 19) chain A residue 114 type sequence F description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 20) chain A residue 205 type sequence I description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 21) chain A residue 208 type sequence V description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 22) chain A residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 23) chain A residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 24) chain A residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 25) chain A residue 301 type sequence T description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 26) chain A residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 27) chain A residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 28) chain A residue 476 type sequence F description BINDING SITE FOR RESIDUE 0XV A 502 source : AC2 29) chain A residue 331 type sequence V description BINDING SITE FOR RESIDUE GOL A 503 source : AC3 30) chain A residue 335 type sequence R description BINDING SITE FOR RESIDUE GOL A 503 source : AC3 31) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 32) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 33) chain A residue 42 type sequence I description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 34) chain A residue 214 type sequence Q description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 35) chain A residue 215 type sequence I description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 36) chain A residue 218 type sequence N description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 37) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 38) chain B residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 39) chain B residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 40) chain B residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 41) chain B residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 42) chain B residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 43) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 44) chain B residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 45) chain B residue 305 type sequence T description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 46) chain B residue 362 type sequence I description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 47) chain B residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 48) chain B residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 49) chain B residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 50) chain B residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 51) chain B residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 52) chain B residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 53) chain B residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 54) chain B residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 55) chain B residue 437 type sequence G description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 56) chain B residue 441 type sequence A description BINDING SITE FOR RESIDUE HEM B 501 source : AC6 57) chain B residue 113 type sequence V description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 58) chain B residue 114 type sequence F description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 59) chain B residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 60) chain B residue 296 type sequence G description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 61) chain B residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 62) chain B residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 63) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 64) chain B residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 65) chain B residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV B 502 source : AC7 66) chain C residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 67) chain C residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 68) chain C residue 113 type sequence V description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 69) chain C residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 70) chain C residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 71) chain C residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 72) chain C residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 73) chain C residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 74) chain C residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 75) chain C residue 305 type sequence T description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 76) chain C residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 77) chain C residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 78) chain C residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 79) chain C residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 80) chain C residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 81) chain C residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 82) chain C residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 83) chain C residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 84) chain C residue 437 type sequence G description BINDING SITE FOR RESIDUE HEM C 501 source : AC8 85) chain C residue 114 type sequence F description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 86) chain C residue 205 type sequence I description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 87) chain C residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 88) chain C residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 89) chain C residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 90) chain C residue 301 type sequence T description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 91) chain C residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 92) chain C residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 93) chain C residue 476 type sequence F description BINDING SITE FOR RESIDUE 0XV C 502 source : AC9 94) chain D residue 97 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 95) chain D residue 112 type sequence I description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 96) chain D residue 113 type sequence V description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 97) chain D residue 120 type sequence W description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 98) chain D residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 99) chain D residue 294 type sequence L description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 100) chain D residue 297 type sequence A description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 101) chain D residue 298 type sequence G description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 102) chain D residue 301 type sequence T description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 103) chain D residue 302 type sequence T description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 104) chain D residue 356 type sequence Q description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 105) chain D residue 362 type sequence I description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 106) chain D residue 365 type sequence S description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 107) chain D residue 368 type sequence H description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 108) chain D residue 427 type sequence P description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 109) chain D residue 428 type sequence F description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 110) chain D residue 429 type sequence S description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 111) chain D residue 433 type sequence R description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 112) chain D residue 435 type sequence C description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 113) chain D residue 436 type sequence V description BINDING SITE FOR RESIDUE HEM D 501 source : BC1 114) chain D residue 205 type sequence I description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 115) chain D residue 293 type sequence D description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 116) chain D residue 297 type sequence A description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 117) chain D residue 300 type sequence E description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 118) chain D residue 362 type sequence I description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 119) chain D residue 366 type sequence L description BINDING SITE FOR RESIDUE 0XV D 502 source : BC2 120) chain A residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1 121) chain B residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1 122) chain C residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1 123) chain D residue 435 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS source Swiss-Prot : SWS_FT_FI1 124) chain A residue 428-437 type prosite sequence FSAGKRICVG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICVG source prosite : PS00086

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