eF-site ID 4gp5-A PDB Code 4gp5 Chain A click to enlarge Title Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133W from Thermus thermophilus Classification OXIDOREDUCTASE Compound Cytochrome c oxidase subunit 1 Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (COXA_THET8) Sequence A:  SRVYEAYPEKKATLYFLVLGFLALIVGSLFGPFQALNYGN VDAYPLLKRLLPFVQSYYQGLTLHGVLNAIVFTQLFAQAI MVYLPARELNMRPNMGLMWLSWWMAFIGLVVAALPLLANE ATVLWTFYPPLKGHWAFYLGASVFVLSTWVSIYIVLDLWR RWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAVLFL LPWSFGLVEGVDPLVARTLFWWTGHPIVYFWLLPAYAIIY TILPKQAGGKLVSDPMARLAFLLFLLLSTPVGFHHQFADP GIDPTWKMIHSVLTLFVAVPSLMTAFTVAASLEFAGRLRG GRGLFGWIRALPWDNPAFVAPVLGLLGFIPGGAGGIVNAS FTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNL TGKPISDAQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNVP RRAYIAQVPDAYPHAAVPMVFNVLAGIVLLVALLLFIYGL FSVLLSRERKPELAEAPLPFAEVIPEDRRLVLAMDRIGFW FAVAAILVVLAYGPTLVQLFGHLNPVPGWRLW Description Functional site 1) chain A residue 233 type sequence H description BINDING SITE FOR RESIDUE CU A 601 source : AC1 2) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE CU A 601 source : AC1 3) chain A residue 283 type sequence H description BINDING SITE FOR RESIDUE CU A 601 source : AC1 4) chain A residue 32 type sequence L description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 5) chain A residue 36 type sequence S description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 6) chain A residue 39 type sequence G description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 7) chain A residue 40 type sequence P description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 8) chain A residue 42 type sequence Q description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 9) chain A residue 43 type sequence A description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 10) chain A residue 46 type sequence Y description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 11) chain A residue 65 type sequence Y description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 12) chain A residue 69 type sequence L description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 13) chain A residue 72 type sequence H description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 14) chain A residue 76 type sequence N description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 15) chain A residue 77 type sequence A description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 16) chain A residue 132 type sequence L description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 17) chain A residue 133 type sequence W description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 18) chain A residue 385 type sequence F description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 19) chain A residue 386 type sequence H description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 20) chain A residue 389 type sequence V description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 21) chain A residue 390 type sequence A description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 22) chain A residue 394 type sequence T description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 23) chain A residue 428 type sequence W description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 24) chain A residue 432 type sequence M description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 25) chain A residue 435 type sequence M description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 26) chain A residue 449 type sequence R description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 27) chain A residue 450 type sequence R description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 28) chain A residue 451 type sequence A description BINDING SITE FOR RESIDUE HEM A 602 source : AC2 29) chain A residue 133 type sequence W description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 30) chain A residue 236 type sequence V description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 31) chain A residue 237 type sequence Y description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 32) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 33) chain A residue 283 type sequence H description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 34) chain A residue 302 type sequence T description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 35) chain A residue 309 type sequence S description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 36) chain A residue 310 type sequence L description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 37) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 38) chain A residue 356 type sequence F description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 39) chain A residue 360 type sequence G description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 40) chain A residue 363 type sequence G description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 41) chain A residue 366 type sequence N description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 42) chain A residue 367 type sequence A description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 43) chain A residue 372 type sequence D description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 44) chain A residue 376 type sequence H description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 45) chain A residue 381 type sequence V description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 46) chain A residue 384 type sequence H description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 47) chain A residue 385 type sequence F description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 48) chain A residue 388 type sequence Q description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 49) chain A residue 449 type sequence R description BINDING SITE FOR RESIDUE HAS A 603 source : AC3 50) chain A residue 233 type sequence H description BINDING SITE FOR RESIDUE PER A 604 source : AC4 51) chain A residue 236 type sequence V description BINDING SITE FOR RESIDUE PER A 604 source : AC4 52) chain A residue 283 type sequence H description BINDING SITE FOR RESIDUE PER A 604 source : AC4 53) chain A residue 161 type sequence Y description BINDING SITE FOR RESIDUE OLC A 605 source : AC5 54) chain A residue 213 type sequence F description BINDING SITE FOR RESIDUE OLC A 606 source : AC6 55) chain A residue 215 type sequence L description BINDING SITE FOR RESIDUE OLC A 606 source : AC6 56) chain A residue 341 type sequence W description BINDING SITE FOR RESIDUE OLC A 606 source : AC6 57) chain A residue 422 type sequence L description BINDING SITE FOR RESIDUE OLC A 606 source : AC6 58) chain A residue 426 type sequence W description BINDING SITE FOR RESIDUE OLC A 606 source : AC6 59) chain A residue 143 type sequence W description BINDING SITE FOR RESIDUE OLC A 607 source : AC7 60) chain A residue 212 type sequence S description BINDING SITE FOR RESIDUE OLC A 607 source : AC7 61) chain A residue 213 type sequence F description BINDING SITE FOR RESIDUE OLC A 607 source : AC7 62) chain A residue 430 type sequence L description BINDING SITE FOR RESIDUE OLC A 607 source : AC7 63) chain A residue 111 type sequence W description BINDING SITE FOR RESIDUE OLC A 608 source : AC8 64) chain A residue 465 type sequence V description BINDING SITE FOR RESIDUE OLC A 608 source : AC8 65) chain A residue 161 type sequence Y description BINDING SITE FOR RESIDUE OLC A 609 source : AC9 66) chain A residue 164 type sequence L description BINDING SITE FOR RESIDUE OLC A 609 source : AC9 67) chain A residue 165 type sequence D description BINDING SITE FOR RESIDUE OLC A 609 source : AC9 68) chain A residue 168 type sequence R description BINDING SITE FOR RESIDUE OLC A 609 source : AC9 69) chain A residue 167 type sequence W description BINDING SITE FOR RESIDUE OLC A 610 source : BC1 70) chain A residue 168 type sequence R description BINDING SITE FOR RESIDUE OLC A 610 source : BC1 71) chain A residue 171 type sequence K description BINDING SITE FOR RESIDUE OLC A 610 source : BC1 72) chain A residue 528 type sequence G description BINDING SITE FOR RESIDUE OLC A 610 source : BC1 73) chain A residue 104 type sequence G description BINDING SITE FOR RESIDUE OLC A 611 source : BC2 74) chain A residue 108 type sequence L description BINDING SITE FOR RESIDUE OLC A 611 source : BC2 75) chain A residue 468 type sequence V description BINDING SITE FOR RESIDUE OLC A 611 source : BC2 76) chain A residue 102 type sequence N description BINDING SITE FOR RESIDUE OLC A 612 source : BC3 77) chain A residue 151 type sequence V description BINDING SITE FOR RESIDUE OLC A 612 source : BC3 78) chain A residue 205 type sequence V description BINDING SITE FOR RESIDUE OLC A 613 source : BC4 79) chain A residue 209 type sequence L description BINDING SITE FOR RESIDUE OLC A 613 source : BC4 80) chain A residue 415 type sequence D description BINDING SITE FOR RESIDUE OLC A 613 source : BC4 81) chain A residue 419 type sequence R description BINDING SITE FOR RESIDUE OLC A 613 source : BC4 82) chain A residue 337 type sequence R description BINDING SITE FOR RESIDUE OLC A 614 source : BC5 83) chain A residue 341 type sequence W description BINDING SITE FOR RESIDUE OLC A 614 source : BC5 84) chain A residue 430 type sequence L description BINDING SITE FOR RESIDUE OLC A 614 source : BC5 85) chain A residue 441 type sequence W description BINDING SITE FOR RESIDUE OLC B 203 source : BC8 86) chain A residue 444 type sequence L description BINDING SITE FOR RESIDUE OLC B 203 source : BC8 87) chain A residue 358 type sequence P description BINDING SITE FOR RESIDUE OLC C 101 source : CC2 88) chain A residue 437 type sequence V description BINDING SITE FOR RESIDUE OLC C 101 source : CC2 89) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE OLC C 101 source : CC2 90) chain A residue 384 type catalytic sequence H description 735 source MCSA : MCSA1 91) chain A residue 385 type catalytic sequence F description 735 source MCSA : MCSA1 92) chain A residue 386 type catalytic sequence H description 735 source MCSA : MCSA1 93) chain A residue 449 type catalytic sequence R description 735 source MCSA : MCSA1 94) chain A residue 450 type catalytic sequence R description 735 source MCSA : MCSA1 95) chain A residue 384 type MOD_RES sequence H description N-formylmethionine => ECO:0000269|PubMed:11152118 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 386 type MOD_RES sequence H description N-formylmethionine => ECO:0000269|PubMed:11152118 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 233 type CROSSLNK sequence H description 1'-histidyl-3'-tyrosine (His-Tyr) source Swiss-Prot : SWS_FT_FI5 98) chain A residue 237 type CROSSLNK sequence Y description 1'-histidyl-3'-tyrosine (His-Tyr) source Swiss-Prot : SWS_FT_FI5 99) chain A residue 385-405 type TRANSMEM sequence FHLQVASLVTLTAMGSLYWLL description Helical source Swiss-Prot : SWS_FT_FI1 100) chain A residue 420-440 type TRANSMEM sequence LGLAVVWLWFLGMMIMAVGLH description Helical source Swiss-Prot : SWS_FT_FI1 101) chain A residue 471-491 type TRANSMEM sequence VLAGIVLLVALLLFIYGLFSV description Helical source Swiss-Prot : SWS_FT_FI1 102) chain A residue 527-547 type TRANSMEM sequence IGFWFAVAAILVVLAYGPTLV description Helical source Swiss-Prot : SWS_FT_FI1 103) chain A residue 74-94 type TRANSMEM sequence VLNAIVFTQLFAQAIMVYLPA description Helical source Swiss-Prot : SWS_FT_FI1 104) chain A residue 105-125 type TRANSMEM sequence LMWLSWWMAFIGLVVAALPLL description Helical source Swiss-Prot : SWS_FT_FI1 105) chain A residue 144-164 type TRANSMEM sequence AFYLGASVFVLSTWVSIYIVL description Helical source Swiss-Prot : SWS_FT_FI1 106) chain A residue 187-207 type TRANSMEM sequence VVFWLMWFLASLGLVLEAVLF description Helical source Swiss-Prot : SWS_FT_FI1 107) chain A residue 227-247 type TRANSMEM sequence LFWWTGHPIVYFWLLPAYAII description Helical source Swiss-Prot : SWS_FT_FI1 108) chain A residue 267-287 type TRANSMEM sequence LAFLLFLLLSTPVGFHHQFAD description Helical source Swiss-Prot : SWS_FT_FI1 109) chain A residue 300-320 type TRANSMEM sequence VLTLFVAVPSLMTAFTVAASL description Helical source Swiss-Prot : SWS_FT_FI1 110) chain A residue 345-365 type TRANSMEM sequence AFVAPVLGLLGFIPGGAGGIV description Helical source Swiss-Prot : SWS_FT_FI1 111) chain A residue 237 type TOPO_DOM sequence Y description Periplasmic source Swiss-Prot : SWS_FT_FI3 112) chain A residue 229-283 type prosite sequence WWTGHPIVYFWLLPAYAIIYTILPKQAGGKLVSDPMARLA FLLFLLLSTPVGFHH description COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WWTGHPiVyfwllpayaiiytilpkqaggklvsdpmarlafllflllstpvgf..HH source prosite : PS00077

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