eF-site ID 4gl9-A PDB Code 4gl9 Chain A click to enlarge Title Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Classification transferase/transferase inhibitor Compound Tyrosine-protein kinase Source (4GL9) Sequence A:  QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVK KLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSNLR LIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEY LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE XXKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE LFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNG RLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQI RDSI Description (1)  Tyrosine-protein kinase (E.C.2.7.10.2), GP130, SOCS3 Functional site 1) chain A residue 855 type sequence L description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 2) chain A residue 880 type sequence A description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 3) chain A residue 929 type sequence M description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 4) chain A residue 930 type sequence E description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 5) chain A residue 932 type sequence L description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 6) chain A residue 933 type sequence P description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 7) chain A residue 935 type sequence G description BINDING SITE FOR RESIDUE IZA A 2001 source : AC1 8) chain A residue 976 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 868 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20304997 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 966 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20304997 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 972 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20304997 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 1008 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20304997 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 1007 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:9473212 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 855 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 882 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 855-883 type prosite sequence LGKGNFGSVEMCRYDPLQDNTGEVVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK source prosite : PS00107 17) chain A residue 972-984 type prosite sequence YIHRDLATRNILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV source prosite : PS00109

Display surface Download Links