eF-site ID 4gjd-AB PDB Code 4gjd Chain A, B click to enlarge Title Crystal structure of renin in complex with NVP-BGQ311 (compound 12) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Renin Source Homo sapiens (Human) (RENI_HUMAN) Sequence A:  TLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGS SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTL RYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFML AEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFY YNRDQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM KGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEA LGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYV FQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYT EFDRRNNRIGFALAR B:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR Description Functional site 1) chain A residue 29-40 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 2) chain A residue 212-223 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 3) chain A residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 7) chain A residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 9) chain B residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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