eF-site ID 4gjb-A
PDB Code 4gjb
Chain A

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Title Crystal structure of renin in complex with NVP-BBV031 (compound 6)
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Renin
Source Homo sapiens (Human) (RENI_HUMAN)
Sequence A:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG
SSNVWVPSSKCSTACVYHKLFDASDSSSYKHNGTELTLRY
STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE
FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN
RDSSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM
KGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEA
LGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYV
FQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYT
EFDRRNNRIGFALAR
Description


Functional site
1) chain A
residue 29-40
type prosite
sequence VVFDTGSSNVWV
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
source prosite : PS00141
2) chain A
residue 212-223
type prosite
sequence ALVDTGASYISG
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
source prosite : PS00141
3) chain A
residue 32
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000269|PubMed:20927107
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 215
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000269|PubMed:20927107
source Swiss-Prot : SWS_FT_FI1
5) chain A
residue -1
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
source Swiss-Prot : SWS_FT_FI2
6) chain A
residue 67
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
source Swiss-Prot : SWS_FT_FI2

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