eF-site ID 4gja-AB PDB Code 4gja Chain A, B click to enlarge Title Crystal structure of renin in complex with NVP-AYL747 (compound 5) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Renin Source Homo sapiens (Human) (RENI_HUMAN) Sequence A:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR B:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR Description (1)  Renin (E.C.3.4.23.15) Functional site 1) chain A residue 38 type ACT_SITE ligand sequence V description source Swiss-Prot : SWS_FT_FI1 2) chain A residue 226 type ACT_SITE ligand sequence S description source Swiss-Prot : SWS_FT_FI1 3) chain B residue 38 type ACT_SITE ligand sequence V description source Swiss-Prot : SWS_FT_FI2 4) chain B residue 226 type ACT_SITE ligand sequence S description source Swiss-Prot : SWS_FT_FI2 5) chain A residue 29-40 type prosite ligand sequence VVFDTGSSNVWV description Eukaryotic and viral aspartyl proteases active site.[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA]. source prosite : PS00141 6) chain B residue 29-40 type prosite ligand sequence VVFDTGSSNVWV description Eukaryotic and viral aspartyl proteases active site.[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA]. source prosite : PS00141 7) chain A residue 212-223 type prosite ligand sequence ALVDTGASYISG description Eukaryotic and viral aspartyl proteases active site.[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA]. source prosite : PS00141 8) chain B residue 212-223 type prosite ligand sequence ALVDTGASYISG description Eukaryotic and viral aspartyl proteases active site.[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA]. source prosite : PS00141

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