eF-site ID 4gja-AB PDB Code 4gja Chain A, B click to enlarge Title Crystal structure of renin in complex with NVP-AYL747 (compound 5) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Renin Source Homo sapiens (Human) (RENI_HUMAN) Sequence A:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR B:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR Description Functional site 1) chain A residue 29-40 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 2) chain A residue 212-223 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141

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