eF-site ID 4g84-B PDB Code 4g84 Chain B click to enlarge Title Crystal structure of human HisRS Classification LIGASE Compound Histidine--tRNA ligase, cytoplasmic Source Homo sapiens (Human) (SYHC_HUMAN) Sequence B:  GPGSEFELRRQFVLKTPKGTRDYSPRQMAVREKVFDVIIR CFKRHGAEVIDTPVFELKETLMSKLIYDLKDQGGELLSLR YDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNRYREFYQC DFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDR RILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMV GEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQ ALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGV IYEAVLLQGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGV ERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLK LVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAII GEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ Description Functional site 1) chain B residue 132 type sequence T description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 2) chain B residue 175 type sequence D description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 3) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 4) chain B residue 331 type sequence Y description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 5) chain B residue 363 type sequence Y description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 6) chain B residue 381 type sequence G description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 7) chain B residue 382 type sequence L description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 8) chain B residue 383 type sequence S description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 9) chain B residue 47 type sequence E description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 10) chain B residue 51 type sequence R description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 11) chain B residue 54 type sequence F description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 12) chain B residue 423 type sequence E description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 13) chain B residue 479 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 14) chain B residue 484 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 15) chain B residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 16) chain B residue 326 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 17) chain B residue 330 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 18) chain B residue 130 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 19) chain B residue 157 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 20) chain B residue 173 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 21) chain B residue 66 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q99KK9 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 356 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI3

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