eF-site ID 4g84-AB PDB Code 4g84 Chain A, B click to enlarge Title Crystal structure of human HisRS Classification LIGASE Compound Histidine--tRNA ligase, cytoplasmic Source Homo sapiens (Human) (SYHC_HUMAN) Sequence A:  VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDT PVFELKETLMGKYGLIYDLKDQGGELLSLRYDLTVPFARY LAMNKLTNIKRYHIAKVYRRDNRYREFYQCDFDIAGNFDP MIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAIC GVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVA DRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKL LFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTP LGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFS IVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSEL WDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQEL KDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ B:  GPGSEFELRRQFVLKTPKGTRDYSPRQMAVREKVFDVIIR CFKRHGAEVIDTPVFELKETLMSKLIYDLKDQGGELLSLR YDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNRYREFYQC DFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDR RILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMV GEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQ ALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGV IYEAVLLQGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGV ERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLK LVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAII GEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ Description Functional site 1) chain A residue 132 type sequence T description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 2) chain A residue 175 type sequence D description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 3) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 4) chain A residue 331 type sequence Y description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 5) chain A residue 360 type sequence G description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 6) chain A residue 363 type sequence Y description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 7) chain A residue 381 type sequence G description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 8) chain A residue 382 type sequence L description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 9) chain A residue 383 type sequence S description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 10) chain B residue 132 type sequence T description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 11) chain B residue 175 type sequence D description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 12) chain B residue 177 type sequence D description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 13) chain B residue 331 type sequence Y description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 14) chain B residue 363 type sequence Y description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 15) chain B residue 381 type sequence G description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 16) chain B residue 382 type sequence L description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 17) chain B residue 383 type sequence S description BINDING SITE FOR RESIDUE IMD B 1001 source : AC2 18) chain B residue 47 type sequence E description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 19) chain B residue 51 type sequence R description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 20) chain B residue 54 type sequence F description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 21) chain B residue 423 type sequence E description BINDING SITE FOR RESIDUE IMD B 1002 source : AC3 22) chain A residue 479 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 23) chain A residue 484 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 24) chain B residue 479 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 25) chain B residue 484 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 26) chain A residue 356 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 356 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 130 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 29) chain B residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 30) chain B residue 326 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 31) chain B residue 330 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 32) chain A residue 157 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 33) chain A residue 173 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 34) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 35) chain A residue 326 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 36) chain A residue 330 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 37) chain B residue 130 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 38) chain B residue 157 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 39) chain B residue 173 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 40) chain A residue 66 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q99KK9 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 66 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q99KK9 source Swiss-Prot : SWS_FT_FI2

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