eF-site ID 4g84-A PDB Code 4g84 Chain A click to enlarge Title Crystal structure of human HisRS Classification LIGASE Compound Histidine--tRNA ligase, cytoplasmic Source Homo sapiens (Human) (SYHC_HUMAN) Sequence A:  VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDT PVFELKETLMGKYGLIYDLKDQGGELLSLRYDLTVPFARY LAMNKLTNIKRYHIAKVYRRDNRYREFYQCDFDIAGNFDP MIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAIC GVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVA DRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKL LFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTP LGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFS IVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSEL WDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQEL KDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ Description Functional site 1) chain A residue 132 type sequence T description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 2) chain A residue 175 type sequence D description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 3) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 4) chain A residue 331 type sequence Y description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 5) chain A residue 360 type sequence G description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 6) chain A residue 363 type sequence Y description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 7) chain A residue 381 type sequence G description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 8) chain A residue 382 type sequence L description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 9) chain A residue 383 type sequence S description BINDING SITE FOR RESIDUE IMD A 1001 source : AC1 10) chain A residue 479 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 11) chain A residue 484 type sequence R description BINDING SITE FOR RESIDUE CL B 1003 source : AC4 12) chain A residue 356 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 130 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 14) chain A residue 157 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 15) chain A residue 173 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 16) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 17) chain A residue 326 type BINDING sequence R description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 18) chain A residue 330 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25151410, ECO:0007744|PDB:4PHC source Swiss-Prot : SWS_FT_FI1 19) chain A residue 66 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q99KK9 source Swiss-Prot : SWS_FT_FI2

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