eF-site ID 4g7y-HLS PDB Code 4g7y Chain H, L, S click to enlarge Title Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A) Classification MEMBRANE PROTEIN Compound Fragment antibody heavy chain Source (4G7Y) Sequence H:  EVQLVESGGGLVQPGGSLRLSCAASGFNVSSSSIHWVRQA PGKGLEWVASISSYYGYTSYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCARSYSWSYAIDYWGQGTLVTVSSA STKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK PSNTKVDKKVEP L:  DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKP GKAPKLLIYSASSLYSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQYFYWPITFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQAGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR S:  RVQFRVRAVIDHLGMRVFGVFLIFLDIILMIIDLSLPGKS ESSQSFYDGMALALSCYFMLDLGLRIFAYGPKNFFTNPWE VADGLIIVVTFVVTIFYTVLDEYVQETGADGLGELVVLAR LLRVVRLARIF Description (1)  Fragment antibody heavy chain, Fragment antibody light chain, Voltage-sensor containing phosphatase Functional site 1) chain L residue 59 type sequence P description BINDING SITE FOR RESIDUE CL L 301 source : AC1 2) chain L residue 59 type sequence P description BINDING SITE FOR RESIDUE CL L 301 source : AC1 3) chain L residue 61 type sequence R description BINDING SITE FOR RESIDUE CL L 301 source : AC1 4) chain L residue 61 type sequence R description BINDING SITE FOR RESIDUE CL L 301 source : AC1 5) chain L residue 167 type sequence D description BINDING SITE FOR RESIDUE MG L 302 source : AC2 6) chain L residue 28 type sequence S description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 7) chain L residue 92 type sequence F description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 8) chain L residue 93 type sequence Y description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 9) chain S residue 196 type sequence V description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 10) chain S residue 199 type sequence F description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 11) chain S residue 204 type sequence D description BINDING SITE FOR RESIDUE LDA S 301 source : AC3 12) chain L residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 13) chain H residue 200-206 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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