eF-site ID 4g21-AB
PDB Code 4g21
Chain A, B

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Title Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
Classification transcription/transcription inhibitor
Compound Vitamin D3 receptor A
Source Danio rerio (Zebrafish) (Brachydanio rerio) (NCOA1_HUMAN)
Sequence A:  HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLS
MLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKS
SAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGH
TLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPG
VQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
B:  RHKILHRLLQE
Description


Functional site

1) chain A
residue 175
type
sequence Y
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

2) chain A
residue 259
type
sequence A
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

3) chain A
residue 261
type
sequence L
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

4) chain A
residue 265
type
sequence S
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

5) chain A
residue 300
type
sequence M
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

6) chain A
residue 302
type
sequence R
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

7) chain A
residue 303
type
sequence S
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

8) chain A
residue 306
type
sequence S
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

9) chain A
residue 328
type
sequence V
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

10) chain A
residue 333
type
sequence H
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

11) chain A
residue 338
type
sequence L
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

12) chain A
residue 423
type
sequence H
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

13) chain A
residue 427
type
sequence Y
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

14) chain A
residue 430
type
sequence L
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

15) chain A
residue 440
type
sequence L
description BINDING SITE FOR RESIDUE 0VP A 501
source : AC1

16) chain A
residue 255
type MOD_RES
sequence L
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 299
type MOD_RES
sequence I
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 333
type MOD_RES
sequence H
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 423
type MOD_RES
sequence H
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1


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