eF-site ID 4g1m-A PDB Code 4g1m Chain A click to enlarge Title Re-refinement of alpha V beta 3 structure Classification PROTEIN BINDING Compound Integrin alpha-V Source (ITB3_HUMAN) Sequence A:  FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGA PKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDY AKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQ EREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFS IDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVY SIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFV SGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSV AATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAI AAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM PPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPV ITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLK ADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPS HSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFME YRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDN VCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYE AELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVV CDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSS NLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNW EHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWP YKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSDIH TLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMN KENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTN VTWGIQPAP Description (1)  Integrin alpha-V, Integrin beta-3 Functional site 1) chain A residue 292 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 349 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 351 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 353 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 355 type TOPO_DOM sequence F description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 357 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 413 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 415 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 417 type TOPO_DOM sequence N description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 419 type TOPO_DOM sequence Y description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 232 type TOPO_DOM sequence N description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 421 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 234 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 236 type TOPO_DOM sequence I description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 238 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 284 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 286 type TOPO_DOM sequence N description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 288 type TOPO_DOM sequence D description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 290 type TOPO_DOM sequence Y description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 266 type BINDING sequence N description in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU source Swiss-Prot : SWS_FT_FI3 21) chain A residue 458 type BINDING sequence N description in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU source Swiss-Prot : SWS_FT_FI3 22) chain A residue 524 type BINDING sequence N description in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU source Swiss-Prot : SWS_FT_FI3 23) chain A residue 943 type BINDING sequence N description in LIMBS binding site => ECO:0007744|PDB:4G1M source Swiss-Prot : SWS_FT_FI6 24) chain A residue 950 type BINDING sequence N description in LIMBS binding site => ECO:0007744|PDB:4G1M source Swiss-Prot : SWS_FT_FI6 25) chain A residue 915 type BINDING sequence N description in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE source Swiss-Prot : SWS_FT_FI7

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