eF-site ID 4g0w-B PDB Code 4g0w Chain B click to enlarge Title Human topoisomerase iibeta in complex with DNA and ametantrone Classification ISOMERASE/DNA/ISOMERASE INHIBITOR Compound DNA topoisomerase 2-beta Source Homo sapiens (Human) (4G0W) Sequence B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFITPFADMERHRILFRYAGP EDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGTKHL TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQ NFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTL ARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA EGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYK NFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQ VYKEQVLEPMLNGPALISDYKEYHTDTTVKFVVKMTEEKL AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQD ILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQGPD FNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPS DLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain B residue 557 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC3 2) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC3 3) chain B residue 867 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC4 4) chain B residue 503 type sequence R description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 5) chain B residue 504 type sequence G description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 6) chain B residue 505 type sequence K description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 7) chain B residue 507 type sequence L description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 8) chain B residue 520 type sequence N description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 9) chain B residue 522 type sequence E description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 10) chain B residue 778 type sequence Q description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 11) chain B residue 782 type sequence M description BINDING SITE FOR RESIDUE AKE D 101 source : AC5 12) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 17) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 18) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 19) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 20) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 21) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 22) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 24) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 25) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 26) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 27) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8

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