eF-site ID 4g0w-AB
PDB Code 4g0w
Chain A, B

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Title Human topoisomerase iibeta in complex with DNA and ametantrone
Classification ISOMERASE/DNA/ISOMERASE INHIBITOR
Compound DNA topoisomerase 2-beta
Source Homo sapiens (Human) (4G0W)
Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV
IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG
LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN
FIHHNWPSLLKHGFLEEFITADMERHRILFRYAGPEDDAA
ITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYNDF
INKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRND
KREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGS
NNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLF
PAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGT
GWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGT
IQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQ
VLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLA
QAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDI
LKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEK
IQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPD
FNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPS
DLWKEDLAAFVEELDKVESQERED
B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG
LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK
IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL
LINFIHHNWPSLLKHGFLEEFITPFADMERHRILFRYAGP
EDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGTKHL
TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC
FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQ
NFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTL
ARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA
EGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYK
NFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQ
VYKEQVLEPMLNGPALISDYKEYHTDTTVKFVVKMTEEKL
AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQD
ILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE
KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQGPD
FNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPS
DLWKEDLAAFVEELDKVESQERED
Description


Functional site

1) chain A
residue 557
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1301
source : AC1

2) chain A
residue 559
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1301
source : AC1

3) chain A
residue 867
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

4) chain A
residue 868
type
sequence G
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

5) chain B
residue 557
type
sequence D
description BINDING SITE FOR RESIDUE MG B 1301
source : AC3

6) chain B
residue 559
type
sequence D
description BINDING SITE FOR RESIDUE MG B 1301
source : AC3

7) chain B
residue 867
type
sequence N
description BINDING SITE FOR RESIDUE MG B 1302
source : AC4

8) chain B
residue 503
type
sequence R
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

9) chain B
residue 504
type
sequence G
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

10) chain B
residue 505
type
sequence K
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

11) chain B
residue 507
type
sequence L
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

12) chain B
residue 520
type
sequence N
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

13) chain B
residue 522
type
sequence E
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

14) chain B
residue 778
type
sequence Q
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

15) chain B
residue 782
type
sequence M
description BINDING SITE FOR RESIDUE AKE D 101
source : AC5

16) chain A
residue 503
type
sequence R
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

17) chain A
residue 505
type
sequence K
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

18) chain A
residue 506
type
sequence I
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

19) chain A
residue 520
type
sequence N
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

20) chain A
residue 522
type
sequence E
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

21) chain A
residue 778
type
sequence Q
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

22) chain A
residue 782
type
sequence M
description BINDING SITE FOR RESIDUE AKE F 101
source : AC7

23) chain A
residue 475-483
type prosite
sequence LTEGDSAKS
description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS
source prosite : PS00177

24) chain A
residue 821
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI1

25) chain B
residue 821
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI1

26) chain A
residue 477
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI2

27) chain B
residue 477
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI2

28) chain A
residue 557
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

29) chain A
residue 559
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

30) chain B
residue 557
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

31) chain B
residue 559
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

32) chain A
residue 505
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

33) chain B
residue 678
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

34) chain B
residue 739
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

35) chain B
residue 947
type SITE
sequence W
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

36) chain A
residue 508
type SITE
sequence N
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

37) chain A
residue 677
type SITE
sequence R
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

38) chain A
residue 678
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

39) chain A
residue 739
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

40) chain A
residue 947
type SITE
sequence W
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

41) chain B
residue 505
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

42) chain B
residue 508
type SITE
sequence N
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

43) chain B
residue 677
type SITE
sequence R
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

44) chain A
residue 773
type SITE
sequence Y
description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI5

45) chain B
residue 773
type SITE
sequence Y
description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI5

46) chain A
residue 820
type SITE
sequence R
description Transition state stabilizer
source Swiss-Prot : SWS_FT_FI6

47) chain B
residue 820
type SITE
sequence R
description Transition state stabilizer
source Swiss-Prot : SWS_FT_FI6

48) chain A
residue 872
type SITE
sequence I
description Important for DNA bending; intercalates between base pairs of target DNA
source Swiss-Prot : SWS_FT_FI7

49) chain B
residue 872
type SITE
sequence I
description Important for DNA bending; intercalates between base pairs of target DNA
source Swiss-Prot : SWS_FT_FI7

50) chain B
residue 671
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

51) chain B
residue 707
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

52) chain B
residue 1087
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

53) chain A
residue 671
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

54) chain A
residue 707
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

55) chain A
residue 1087
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8


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