|
|
eF-site ID
|
4fx3-D |
|
PDB Code
|
4fx3 |
|
Chain
|
D |
|
click to enlarge
|
|
|
Title
|
Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor |
|
Classification
|
transferase/transferase inhibitor |
|
Compound
|
Cyclin-dependent kinase 2 |
|
Source
|
Homo sapiens (Human) (CCNA2_HUMAN) |
|
|
Sequence
|
D: |
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
210 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE DTT D 501
|
| source |
: AC5
|
|
|
2)
|
chain |
D |
| residue |
213 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE DTT D 501
|
| source |
: AC5
|
|
|
3)
|
chain |
D |
| residue |
214 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE DTT D 501
|
| source |
: AC5
|
|
|
4)
|
chain |
D |
| residue |
254 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE DTT D 501
|
| source |
: AC5
|
|
|
|