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eF-site ID
|
4fx3-B |
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PDB Code
|
4fx3 |
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Chain
|
B |
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click to enlarge
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Title
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Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor |
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Classification
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transferase/transferase inhibitor |
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Compound
|
Cyclin-dependent kinase 2 |
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Source
|
Homo sapiens (Human) (CCNA2_HUMAN) |
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Sequence
|
B: |
PDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILV
DWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL
VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRME
HLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMF
LGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPES
LIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKN
SKYHGVSLLNPPETLNL
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
213 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE DTT B 501
|
| source |
: AC3
|
|
|
2)
|
chain |
B |
| residue |
214 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE DTT B 501
|
| source |
: AC3
|
|
|
3)
|
chain |
B |
| residue |
253 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE DTT B 501
|
| source |
: AC3
|
|
|
4)
|
chain |
B |
| residue |
211-242 |
| type |
prosite |
| sequence |
RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
|
| description |
CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
|
| source |
prosite : PS00292
|
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