eF-site ID 4fl9-A PDB Code 4fl9 Chain A click to enlarge Title Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution Classification TRANSCRIPTION Compound Heat shock cognate 71 kDa protein Source Bos taurus (Bovine) (HSP7C_BOVIN) Sequence A:  GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVA FTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVV QSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMV LTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGT IAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG TFDVSILTIAAGIFEVKSTAGDTHLGGEDFDNRMVNHFIA EFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIE IDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRD AKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSI NPDEAVAYGAAVQAAILSGDDVTPLSLGIETAGGVMTVLI KRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN LLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKS TGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRD KVSSKNSLESYAFNMKATV Description Functional site 1) chain A residue 15 type sequence Y description BINDING SITE FOR RESIDUE TMO A 601 source : AC1 2) chain A residue 37 type sequence T description BINDING SITE FOR RESIDUE TMO A 601 source : AC1 3) chain A residue 366 type sequence D description BINDING SITE FOR RESIDUE TMO A 601 source : AC1 4) chain A residue 148 type sequence A description BINDING SITE FOR RESIDUE TMO A 602 source : AC2 5) chain A residue 150 type sequence F description BINDING SITE FOR RESIDUE TMO A 602 source : AC2 6) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE TMO A 602 source : AC2 7) chain A residue 523 type sequence E description BINDING SITE FOR RESIDUE TMO A 602 source : AC2 8) chain A residue 524 type sequence K description BINDING SITE FOR RESIDUE TMO A 602 source : AC2 9) chain A residue 13 type sequence T description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 10) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 11) chain A residue 76 type sequence R description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 12) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 13) chain A residue 86 type sequence D description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 14) chain A residue 149 type sequence Y description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 15) chain A residue 226 type sequence T description BINDING SITE FOR RESIDUE DTT A 603 source : AC3 16) chain A residue 10 type catalytic sequence D description 656 source MCSA : MCSA1 17) chain A residue 71 type catalytic sequence K description 656 source MCSA : MCSA1 18) chain A residue 175 type catalytic sequence E description 656 source MCSA : MCSA1 19) chain A residue 199 type catalytic sequence D description 656 source MCSA : MCSA1 20) chain A residue 469 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI8 21) chain A residue 9-16 type prosite sequence IDLGTTYS description HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS source prosite : PS00297 22) chain A residue 197-210 type prosite sequence IFDLGGGTFDVSIL description HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL source prosite : PS00329 23) chain A residue 334-348 type prosite sequence IVLVGGSTRIPKIQK description HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK source prosite : PS01036 24) chain A residue 512 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI9 25) chain A residue 14 type BINDING sequence T description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 26) chain A residue 15 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 27) chain A residue 202 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 28) chain A residue 268 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 29) chain A residue 271 type BINDING sequence K description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 30) chain A residue 275 type BINDING sequence S description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 31) chain A residue 339 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 32) chain A residue 108 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 328 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 524 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 153 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 36) chain A residue 329 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 37) chain A residue 362 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 38) chain A residue 541 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 39) chain A residue 246 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI6 40) chain A residue 319 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI7 41) chain A residue 512 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI7 42) chain A residue 12 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 43) chain A residue 71 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1

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