eF-site ID 4fhj-A
PDB Code 4fhj
Chain A

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Title Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2
Classification Transferase/Inhibitor
Compound Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Source Homo sapiens (Human) (PK3CG_HUMAN)
Sequence A:  EESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPR
MAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVI
HRSTTSQTIKVSPDDTPGAILQSFFTKMDFVLRVCGRDEY
LVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRK
ECDRKFRVKIRGIDIPVLDLTVFVEANIQHGQQVLCQRRT
SPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCVQLL
YYVNLLLIDHRFLLRRGEYVLHMWQISSFNADKLTSATNP
DKENSMSISILLDNEMPNQLRKQLEAIIATDPLNPLTAED
KELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLL
ARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESL
EDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRI
GHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHD
FTQQVQVIEMLQKVTLDIKSLKYDVSSQVISQLKQKLENL
QNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLE
FKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESI
WETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQS
TVGNAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYC
VATFVLGIGDRHNDNIMITETGNLFHIDFGHIKERVPFVL
TPDFLFVMGTSKTSPHFQKFQDICVKAYLALRHHTNLLII
LFSMMLMTGMSKEDIEYIRDALTVGKNEEDAKKYFLDQIE
VCRDKGWTVQFNWFLHLVL
Description


Functional site

1) chain A
residue 206
type
sequence P
description BINDING SITE FOR RESIDUE SO4 A 1201
source : AC1

2) chain A
residue 207
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 1201
source : AC1

3) chain A
residue 212
type
sequence W
description BINDING SITE FOR RESIDUE SO4 A 1201
source : AC1

4) chain A
residue 288
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 1201
source : AC1

5) chain A
residue 546
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A 1202
source : AC2

6) chain A
residue 576
type
sequence W
description BINDING SITE FOR RESIDUE SO4 A 1202
source : AC2

7) chain A
residue 579
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1202
source : AC2

8) chain A
residue 606
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 1202
source : AC2

9) chain A
residue 657
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 1203
source : AC3

10) chain A
residue 694
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 1203
source : AC3

11) chain A
residue 698
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 1203
source : AC3

12) chain A
residue 846
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 1203
source : AC3

13) chain A
residue 849
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1203
source : AC3

14) chain A
residue 947
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1204
source : AC4

15) chain A
residue 948
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 1204
source : AC4

16) chain A
residue 951
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 1204
source : AC4

17) chain A
residue 1086
type
sequence W
description BINDING SITE FOR RESIDUE SO4 A 1204
source : AC4

18) chain A
residue 804
type
sequence M
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

19) chain A
residue 806
type
sequence S
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

20) chain A
residue 831
type
sequence I
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

21) chain A
residue 833
type
sequence K
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

22) chain A
residue 836
type
sequence D
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

23) chain A
residue 841
type
sequence D
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

24) chain A
residue 867
type
sequence Y
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

25) chain A
residue 879
type
sequence I
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

26) chain A
residue 880
type
sequence E
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

27) chain A
residue 882
type
sequence V
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

28) chain A
residue 953
type
sequence M
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

29) chain A
residue 963
type
sequence I
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

30) chain A
residue 964
type
sequence D
description BINDING SITE FOR RESIDUE 0TZ A 1205
source : AC5

31) chain A
residue 832-846
type prosite
sequence FKHGDDLRQDMLILQ
description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
source prosite : PS00915

32) chain A
residue 931-951
type prosite
sequence SCAGYCVATFVLGIGDRHNDN
description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
source prosite : PS00916

33) chain A
residue 829
type BINDING
sequence G
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 864
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 961
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 1024
type MOD_RES
sequence T
description Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7
source Swiss-Prot : SWS_FT_FI2


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