eF-site ID 4fao-ABCDEFGHIJKLMNOPQRSTUVWXabcdefghijkl PDB Code 4fao Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, a, b, c, d, e, f, g, h, i, j, k, l click to enlarge Title Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex Classification SIGNALING PROTEIN/SIGNALING PROTEIN Compound Growth/differentiation factor 2 Source (AVR2B_HUMAN) Sequence A:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR B:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR C:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE D:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL E:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP F:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP G:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR H:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR I:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE J:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL K:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP L:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP M:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR N:  HCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLA DDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLY KDDMGVPTLKYHYEGMSVAECGCR O:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE P:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL Q:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP R:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP S:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR T:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR U:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE V:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL W:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP X:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP a:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR b:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR c:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE d:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL e:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP f:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP g:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR h:  SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVL YKDDMGVPTLKYHYEGMSVAECGCR i:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE j:  PLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGC GNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL k:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP l:  RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNS SGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG NFCNERFTHLP Description Functional site 1) chain E residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 2) chain E residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 3) chain F residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 4) chain F residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 5) chain K residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 6) chain K residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 7) chain L residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 8) chain L residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 9) chain Q residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 10) chain Q residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 11) chain R residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 12) chain R residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 13) chain W residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 14) chain W residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 15) chain X residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 16) chain X residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 17) chain e residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 18) chain e residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 19) chain f residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 20) chain f residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 21) chain k residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 22) chain k residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 23) chain l residue 24 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 24) chain l residue 47 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22718755 source Swiss-Prot : SWS_FT_FI1 25) chain C residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 26) chain D residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 27) chain I residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 28) chain J residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 29) chain O residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 30) chain P residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 31) chain U residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 32) chain V residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 33) chain c residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 34) chain d residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 35) chain i residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 36) chain j residue 98 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 26-41 type prosite sequence IIAPKEYEAYECKGGC description TGF_BETA_1 TGF-beta family signature. IiaPkeYeayeCkGgC source prosite : PS00250

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