eF-site ID 4f7n-B PDB Code 4f7n Chain B click to enlarge Title Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea) Classification TRANSFERASE/TRANSCRIPTION/INHIBITOR Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence B:  DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEY WKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYS LKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLK TRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYR PLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMI ALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKL YEQWKNFDERKEMATILSKMPKPKPPPN Description Functional site 1) chain B residue 9 type sequence S description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 2) chain B residue -1 type sequence K description BINDING SITE FOR RESIDUE EDO B 301 source : AC3 3) chain B residue 0 type sequence A description BINDING SITE FOR RESIDUE EDO B 301 source : AC3 4) chain B residue 152 type sequence V description BINDING SITE FOR RESIDUE EDO B 301 source : AC3

Display surface Download Links