eF-site ID 4f7n-A PDB Code 4f7n Chain A click to enlarge Title Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea) Classification TRANSFERASE/TRANSCRIPTION/INHIBITOR Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence A:  KMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAK RKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVI SLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASVQLPR GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE RGRVKIADMGFVVTFWYRAPELLLGARHYTKAIDIWAIGC IFAELLTSEPIFHCRQENPYHHDQLDRIFNVMGFPADKDW EDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSK AFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFA GCQIPYPKREFLTE Description Functional site 1) chain A residue 50 type sequence A description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 2) chain A residue 62 type sequence S description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 3) chain A residue 65 type sequence R description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 4) chain A residue 66 type sequence E description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 5) chain A residue 73 type sequence L description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 6) chain A residue 79 type sequence I description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 7) chain A residue 98 type sequence D description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 8) chain A residue 99 type sequence Y description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 9) chain A residue 100 type sequence A description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 10) chain A residue 172 type sequence A description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 11) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE 0SV A 501 source : AC1 12) chain A residue 71 type sequence R description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 13) chain A residue 72 type sequence E description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 14) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 17) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108

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