eF-site ID 4f3l-B PDB Code 4f3l Chain B click to enlarge Title Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex Classification TRANSCRIPTION/ACTIVATOR Compound BMAL1b Source (CLOCK_MOUSE) Sequence B:  KNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLD KLTVLRMAVQHMKTLRGAANYKPTFLSDDELKHLILRAAD GFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYL HPKDIAKVKEQLSSSRLCSGARRSFFCRMKCNRPRKSFCT IHSTGYLKSNLSCLVAIGRLHSHMVPQPANGEIRVKSMEY VSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQD DIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRW FSFMNPWTKEVEYIVSTNTVVL Description Functional site 1) chain B residue 77 type SITE sequence H description Interaction with E-box DNA => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 80 type SITE sequence I description Interaction with E-box DNA => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 81 type SITE sequence E description Interaction with E-box DNA => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 85 type SITE sequence R description Interaction with E-box DNA => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 125 type SITE sequence L description Important for interaction with CLOCK => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 78 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:O00327 source Swiss-Prot : SWS_FT_FI3 7) chain B residue 90 type MOD_RES sequence S description Phosphoserine; by CK2 => ECO:0000269|PubMed:19330005 source Swiss-Prot : SWS_FT_FI4 8) chain B residue 252 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3) => ECO:0000269|PubMed:18644859 source Swiss-Prot : SWS_FT_FI5

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