eF-site ID 4ewh-A PDB Code 4ewh Chain A click to enlarge Title Co-crystal structure of ACK1 with inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Activated CDC42 kinase 1 Source Homo sapiens (Human) (ACK1_HUMAN) Sequence A:  LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVA VKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVV LTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA LPQNDDHXVMQEHRKVPFAWCAPESLKTRTFSHASDTWMF GVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPT Description (1)  Activated CDC42 kinase 1 (E.C.2.7.10.2, 2.7.11.1) Functional site 1) chain A residue 132 type sequence L description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 2) chain A residue 133 type sequence G description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 3) chain A residue 134 type sequence D description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 4) chain A residue 156 type sequence A description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 5) chain A residue 206 type sequence E description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 6) chain A residue 208 type sequence A description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 7) chain A residue 209 type sequence P description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 8) chain A residue 210 type sequence L description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 9) chain A residue 211 type sequence G description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 10) chain A residue 219 type sequence K description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 11) chain A residue 256 type sequence R description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 12) chain A residue 259 type sequence L description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 13) chain A residue 269 type sequence G description BINDING SITE FOR RESIDUE T77 A 401 source : AC2 14) chain A residue 252 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 15) chain A residue 132 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 16) chain A residue 158 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 17) chain A residue 284 type MOD_RES sequence X description Phosphotyrosine; by SRC and autocatalysis => ECO:0000269|PubMed:15308621, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20623637, ECO:0000269|PubMed:20979614, ECO:0000269|PubMed:21169560, ECO:0000269|PubMed:21309750, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI3

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