|
|
eF-site ID
|
4eu2-Y |
|
PDB Code
|
4eu2 |
|
Chain
|
Y |
|
click to enlarge
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|
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Title
|
Crystal structure of 20s proteasome with novel inhibitor K-7174 |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Proteasome component C7-alpha |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
Y: |
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSP
HTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAV
SSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQID
YLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDL
LKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQ
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
Y |
| residue |
48 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
2)
|
chain |
Y |
| residue |
98 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
|