eF-site ID 4eu2-I PDB Code 4eu2 Chain I click to enlarge Title Crystal structure of 20s proteasome with novel inhibitor K-7174 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component C7-alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence I:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain I residue 1 type sequence T description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 2) chain I residue 46 type sequence A description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 3) chain I residue 47 type sequence G description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 4) chain I residue 128 type sequence G description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 5) chain I residue 129 type sequence S description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 6) chain I residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 7) chain I residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 8) chain I residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 9) chain I residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 10) chain I residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 11) chain I residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 12) chain I residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 13) chain I residue 169 type catalytic sequence S description 177 source MCSA : MCSA1 14) chain I residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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