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eF-site ID
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4eu2-1 |
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PDB Code
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4eu2 |
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Chain
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1 |
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click to enlarge
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Title
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Crystal structure of 20s proteasome with novel inhibitor K-7174 |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome component C7-alpha |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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1: |
QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE
PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN
DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG
AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY
EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
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Description
|
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Functional site
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|
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1)
|
chain |
1 |
| residue |
24 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE WPI I 301
|
| source |
: AC2
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2)
|
chain |
1 |
| residue |
4-51 |
| type |
prosite |
| sequence |
LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM
SANGFAAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD
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| source |
prosite : PS00854
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