|
|
eF-site ID
|
4eu2-Z |
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PDB Code
|
4eu2 |
|
Chain
|
Z |
|
click to enlarge
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Title
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Crystal structure of 20s proteasome with novel inhibitor K-7174 |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome component C7-alpha |
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Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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Z: |
TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKRVIEINPF
LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS
KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT
RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS
ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG
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Description
|
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Functional site
|
|
|
1)
|
chain |
Z |
| residue |
1 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
2)
|
chain |
Z |
| residue |
91 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
3)
|
chain |
Z |
| residue |
118 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
4)
|
chain |
Z |
| residue |
130 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
5)
|
chain |
Z |
| residue |
131 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE WPI Z 301
|
| source |
: AC6
|
|
|
6)
|
chain |
Z |
| residue |
1 |
| type |
ACT_SITE |
| sequence |
T
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
Z |
| residue |
49 |
| type |
BINDING |
| sequence |
A
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|