eF-site ID 4eu2-W PDB Code 4eu2 Chain W click to enlarge Title Crystal structure of 20s proteasome with novel inhibitor K-7174 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component C7-alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence W:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain W residue 1 type sequence T description BINDING SITE FOR RESIDUE WPI W 301 source : AC5 2) chain W residue 47 type sequence G description BINDING SITE FOR RESIDUE WPI W 301 source : AC5 3) chain W residue 97 type sequence Y description BINDING SITE FOR RESIDUE WPI W 301 source : AC5 4) chain W residue 129 type sequence S description BINDING SITE FOR RESIDUE WPI W 301 source : AC5 5) chain W residue 1 type catalytic sequence T description 177 source MCSA : MCSA2 6) chain W residue 17 type catalytic sequence D description 177 source MCSA : MCSA2 7) chain W residue 19 type catalytic sequence R description 177 source MCSA : MCSA2 8) chain W residue 33 type catalytic sequence K description 177 source MCSA : MCSA2 9) chain W residue 47 type catalytic sequence G description 177 source MCSA : MCSA2 10) chain W residue 129 type catalytic sequence S description 177 source MCSA : MCSA2 11) chain W residue 166 type catalytic sequence D description 177 source MCSA : MCSA2 12) chain W residue 169 type catalytic sequence S description 177 source MCSA : MCSA2

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