|
|
eF-site ID
|
4eu2-V |
|
PDB Code
|
4eu2 |
|
Chain
|
V |
|
click to enlarge
|
|
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Title
|
Crystal structure of 20s proteasome with novel inhibitor K-7174 |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Proteasome component C7-alpha |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
V: |
TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
V |
| residue |
46 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE WPI V 201
|
| source |
: AC4
|
|
|
2)
|
chain |
V |
| residue |
94 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE WPI V 201
|
| source |
: AC4
|
|
|
3)
|
chain |
V |
| residue |
115 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE WPI V 201
|
| source |
: AC4
|
|
|
4)
|
chain |
V |
| residue |
128 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE WPI V 201
|
| source |
: AC4
|
|
|
5)
|
chain |
V |
| residue |
129 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE WPI V 201
|
| source |
: AC4
|
|
|
6)
|
chain |
V |
| residue |
94 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE WPI W 301
|
| source |
: AC5
|
|
|
|