|
|
eF-site ID
|
4eu2-N |
|
PDB Code
|
4eu2 |
|
Chain
|
N |
|
click to enlarge
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Title
|
Crystal structure of 20s proteasome with novel inhibitor K-7174 |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Proteasome component C7-alpha |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
N: |
TQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVE
RLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPL
ADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQ
SNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVD
RESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAII
DKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
N |
| residue |
-5 |
| type |
|
| sequence |
P
|
| description |
BINDING SITE FOR RESIDUE WPI H 300
|
| source |
: AC1
|
|
|
2)
|
chain |
N |
| residue |
-2 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE WPI H 300
|
| source |
: AC1
|
|
|
3)
|
chain |
N |
| residue |
22 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE WPI H 300
|
| source |
: AC1
|
|
|
|