eF-site ID 4eu2-L PDB Code 4eu2 Chain L click to enlarge Title Crystal structure of 20s proteasome with novel inhibitor K-7174 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component C7-alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence L:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKRVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain L residue 1 type sequence T description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 2) chain L residue 47 type sequence G description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 3) chain L residue 97 type sequence M description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 4) chain L residue 118 type sequence D description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 5) chain L residue 130 type sequence G description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 6) chain L residue 131 type sequence S description BINDING SITE FOR RESIDUE WPI L 301 source : AC3 7) chain L residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1 8) chain L residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 9) chain L residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKRVIEINPFLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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