eF-site ID 4eu2-H PDB Code 4eu2 Chain H click to enlarge Title Crystal structure of 20s proteasome with novel inhibitor K-7174 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component C7-alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence H:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain H residue 1 type sequence T description BINDING SITE FOR RESIDUE WPI H 300 source : AC1 2) chain H residue 128 type sequence G description BINDING SITE FOR RESIDUE WPI H 300 source : AC1 3) chain H residue 129 type sequence S description BINDING SITE FOR RESIDUE WPI H 300 source : AC1 4) chain H residue 22 type sequence T description BINDING SITE FOR RESIDUE WPI I 301 source : AC2 5) chain H residue 4-51 type prosite sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC CRSGSAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVtFkdGVILGADsrtttgayianrvtd.KltrvhdkiwccrsGsaAD source prosite : PS00854

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