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eF-site ID
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4eu2-D |
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PDB Code
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4eu2 |
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Chain
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D |
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click to enlarge
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Title
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Crystal structure of 20s proteasome with novel inhibitor K-7174 |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome component C7-alpha |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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D: |
GYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCV
VLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADS
RILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQ
SGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQ
TIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEV
VQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQE
Q
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Description
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Functional site
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1)
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chain |
D |
| residue |
4-26 |
| type |
prosite |
| sequence |
YDRALSIFSPDGHIFQVEYALEA
|
| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA
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| source |
prosite : PS00388
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2)
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chain |
D |
| residue |
34-81 |
| type |
prosite |
| sequence |
VGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVL
SFSGLNAD
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| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
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| source |
prosite : PS00854
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